Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects the nasopharynx and lungs and causes coronavirus disease-2019 (COVID-19). It may impact the heart, brain, kidney, and liver.(1) Although functional impairment of the liver has been correlated with worse clinical outcomes, little is...

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Autores principales: Kaltschmidt, Barbara, Fitzek, Antonia D.E., Schaedler, Julia, Förster, Christine, Kaltschmidt, Christian, Hansen, Torsten, Steinfurth, Fabian, Windmöller, Beatrice A., Pilger, Christian, Kong, Cihang, Singh, Kashika, Nierhaus, Axel, Wichmann, Dominic, Sperhake, Jan, Püschel, Klaus, Huser, Thomas, Krüger, Martin, Robson, Simon C., Wilkens, Ludwig, Schulte am Esch, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. on behalf of the AGA Institute. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844358/
https://www.ncbi.nlm.nih.gov/pubmed/33516952
http://dx.doi.org/10.1016/j.cgh.2021.01.044
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author Kaltschmidt, Barbara
Fitzek, Antonia D.E.
Schaedler, Julia
Förster, Christine
Kaltschmidt, Christian
Hansen, Torsten
Steinfurth, Fabian
Windmöller, Beatrice A.
Pilger, Christian
Kong, Cihang
Singh, Kashika
Nierhaus, Axel
Wichmann, Dominic
Sperhake, Jan
Püschel, Klaus
Huser, Thomas
Krüger, Martin
Robson, Simon C.
Wilkens, Ludwig
Schulte am Esch, Jan
author_facet Kaltschmidt, Barbara
Fitzek, Antonia D.E.
Schaedler, Julia
Förster, Christine
Kaltschmidt, Christian
Hansen, Torsten
Steinfurth, Fabian
Windmöller, Beatrice A.
Pilger, Christian
Kong, Cihang
Singh, Kashika
Nierhaus, Axel
Wichmann, Dominic
Sperhake, Jan
Püschel, Klaus
Huser, Thomas
Krüger, Martin
Robson, Simon C.
Wilkens, Ludwig
Schulte am Esch, Jan
author_sort Kaltschmidt, Barbara
collection PubMed
description Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects the nasopharynx and lungs and causes coronavirus disease-2019 (COVID-19). It may impact the heart, brain, kidney, and liver.(1) Although functional impairment of the liver has been correlated with worse clinical outcomes, little is known about the pathophysiology of hepatic injury and repair in COVID-19.(2)(,)(3) Histologic evaluation has been limited to small numbers of COVID-19 cases with no control subjects(2)(,)(4) and demonstrated largely heterogeneous patterns of pathology.(2)(,)(3)
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spelling pubmed-78443582021-01-29 Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19 Kaltschmidt, Barbara Fitzek, Antonia D.E. Schaedler, Julia Förster, Christine Kaltschmidt, Christian Hansen, Torsten Steinfurth, Fabian Windmöller, Beatrice A. Pilger, Christian Kong, Cihang Singh, Kashika Nierhaus, Axel Wichmann, Dominic Sperhake, Jan Püschel, Klaus Huser, Thomas Krüger, Martin Robson, Simon C. Wilkens, Ludwig Schulte am Esch, Jan Clin Gastroenterol Hepatol Original Article Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects the nasopharynx and lungs and causes coronavirus disease-2019 (COVID-19). It may impact the heart, brain, kidney, and liver.(1) Although functional impairment of the liver has been correlated with worse clinical outcomes, little is known about the pathophysiology of hepatic injury and repair in COVID-19.(2)(,)(3) Histologic evaluation has been limited to small numbers of COVID-19 cases with no control subjects(2)(,)(4) and demonstrated largely heterogeneous patterns of pathology.(2)(,)(3) The Authors. Published by Elsevier Inc. on behalf of the AGA Institute. 2021-08 2021-01-29 /pmc/articles/PMC7844358/ /pubmed/33516952 http://dx.doi.org/10.1016/j.cgh.2021.01.044 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Kaltschmidt, Barbara
Fitzek, Antonia D.E.
Schaedler, Julia
Förster, Christine
Kaltschmidt, Christian
Hansen, Torsten
Steinfurth, Fabian
Windmöller, Beatrice A.
Pilger, Christian
Kong, Cihang
Singh, Kashika
Nierhaus, Axel
Wichmann, Dominic
Sperhake, Jan
Püschel, Klaus
Huser, Thomas
Krüger, Martin
Robson, Simon C.
Wilkens, Ludwig
Schulte am Esch, Jan
Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19
title Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19
title_full Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19
title_fullStr Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19
title_full_unstemmed Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19
title_short Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19
title_sort hepatic vasculopathy and regenerative responses of the liver in fatal cases of covid-19
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844358/
https://www.ncbi.nlm.nih.gov/pubmed/33516952
http://dx.doi.org/10.1016/j.cgh.2021.01.044
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