Suppression of local type I interferon by gut microbiota–derived butyrate impairs antitumor effects of ionizing radiation

The antitumor effects of ionizing radiation (IR) are mediated in part through activation of innate and adaptive immunity. Here we report that gut microbiota influences tumor control following IR. Vancomycin decreased the abundance of butyrate-producing gut bacteria and enhanced antitumor responses t...

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Detalles Bibliográficos
Autores principales: Yang, Kaiting, Hou, Yuzhu, Zhang, Yuan, Liang, Hua, Sharma, Anukriti, Zheng, Wenxin, Wang, Liangliang, Torres, Rolando, Tatebe, Ken, Chmura, Steven J., Pitroda, Sean P., Gilbert, Jack A., Fu, Yang-Xin, Weichselbaum, Ralph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844434/
https://www.ncbi.nlm.nih.gov/pubmed/33496784
http://dx.doi.org/10.1084/jem.20201915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844434/
https://www.ncbi.nlm.nih.gov/pubmed/33496784
http://dx.doi.org/10.1084/jem.20201915

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