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Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016
BACKGROUND: Previous studies have suggested that the possible relationship between serum uric acid (SUA) and testosterone. However, the results of previous studies are controversial and there is limited evidence examining the relationship between SUA and testosterone in a general US population of me...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844527/ https://www.ncbi.nlm.nih.gov/pubmed/33532316 http://dx.doi.org/10.21037/tau-20-1114 |
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author | Han, Yingdong Zhang, Yun Cao, Yu Yin, Yue Han, Xinxin Di, Hong Chu, Xiaotian Zeng, Xuejun |
author_facet | Han, Yingdong Zhang, Yun Cao, Yu Yin, Yue Han, Xinxin Di, Hong Chu, Xiaotian Zeng, Xuejun |
author_sort | Han, Yingdong |
collection | PubMed |
description | BACKGROUND: Previous studies have suggested that the possible relationship between serum uric acid (SUA) and testosterone. However, the results of previous studies are controversial and there is limited evidence examining the relationship between SUA and testosterone in a general US population of men. The objective of this study is to explore the correlation of SUA and testosterone among adult males from the US. METHODS: Data from the National Health and Nutrition Examination Survey 2011–2016 were used, including a total of 7,796 male participants aged 18 years or older and excluding those lacking serum testosterone and uric acid data. Clinical characteristics of the participants among different SUA groups and testosterone groups are compared. Univariate and multivariate linear regression analyses were applied to evaluate the association between SUA and testosterone. RESULTS: We found an inverse association between SUA and testosterone after fully adjusted the potential confounding factors in general US adult males. In the multivariate linear regression analysis, we found that increasing age (estimate testosterone percent difference: −0.20% per year, P<0.01), uric acid (estimate testosterone percent difference: −4.40% per md/dL, P<0.01) and BMI (estimate testosterone percent difference: −2.86% per kg/m2, P<0.01) were associated with declining serum testosterone. This association remained significant in sensitivity analysis, while in the stratified analysis, above association was not significant in men with diabetes or aged 65 and over. CONCLUSIONS: SUA levels might be negatively associated with serum testosterone in adult males. |
format | Online Article Text |
id | pubmed-7844527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-78445272021-02-01 Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016 Han, Yingdong Zhang, Yun Cao, Yu Yin, Yue Han, Xinxin Di, Hong Chu, Xiaotian Zeng, Xuejun Transl Androl Urol Original Article BACKGROUND: Previous studies have suggested that the possible relationship between serum uric acid (SUA) and testosterone. However, the results of previous studies are controversial and there is limited evidence examining the relationship between SUA and testosterone in a general US population of men. The objective of this study is to explore the correlation of SUA and testosterone among adult males from the US. METHODS: Data from the National Health and Nutrition Examination Survey 2011–2016 were used, including a total of 7,796 male participants aged 18 years or older and excluding those lacking serum testosterone and uric acid data. Clinical characteristics of the participants among different SUA groups and testosterone groups are compared. Univariate and multivariate linear regression analyses were applied to evaluate the association between SUA and testosterone. RESULTS: We found an inverse association between SUA and testosterone after fully adjusted the potential confounding factors in general US adult males. In the multivariate linear regression analysis, we found that increasing age (estimate testosterone percent difference: −0.20% per year, P<0.01), uric acid (estimate testosterone percent difference: −4.40% per md/dL, P<0.01) and BMI (estimate testosterone percent difference: −2.86% per kg/m2, P<0.01) were associated with declining serum testosterone. This association remained significant in sensitivity analysis, while in the stratified analysis, above association was not significant in men with diabetes or aged 65 and over. CONCLUSIONS: SUA levels might be negatively associated with serum testosterone in adult males. AME Publishing Company 2021-01 /pmc/articles/PMC7844527/ /pubmed/33532316 http://dx.doi.org/10.21037/tau-20-1114 Text en 2021 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Han, Yingdong Zhang, Yun Cao, Yu Yin, Yue Han, Xinxin Di, Hong Chu, Xiaotian Zeng, Xuejun Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016 |
title | Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016 |
title_full | Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016 |
title_fullStr | Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016 |
title_full_unstemmed | Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016 |
title_short | Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016 |
title_sort | exploration of the association between serum uric acid and testosterone in adult males: nhanes 2011–2016 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844527/ https://www.ncbi.nlm.nih.gov/pubmed/33532316 http://dx.doi.org/10.21037/tau-20-1114 |
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