Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults

Colonization of the upper respiratory tract with Streptococcus pneumoniae is the precursor of pneumococcal pneumonia and invasive disease. Following exposure, however, it is unclear which human immune mechanisms determine whether a pathogen will colonize. We used a human challenge model to investiga...

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Detalles Bibliográficos
Autores principales: Nikolaou, Elissavet, Jochems, Simon P., Mitsi, Elena, Pojar, Sherin, Blizard, Annie, Reiné, Jesus, Solórzano, Carla, Negera, Edessa, Carniel, Beatriz, Soares-Schanoski, Alessandra, Connor, Victoria, Adler, Hugh, Zaidi, Seher R., Hales, Caz, Hill, Helen, Hyder-Wright, Angie, Gordon, Stephen B., Rylance, Jamie, Ferreira, Daniela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844534/
https://www.ncbi.nlm.nih.gov/pubmed/33436429
http://dx.doi.org/10.1128/mBio.02020-20

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