Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway

Rap2B, belonging to the Ras superfamily, has been implicated in cancer development and functions as a tumor promoter. However, the role of Rap2B in cervical cancer is unknown. In this study, we investigated the expression pattern and biological functions of Rap2B in cervical cancer. The results show...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yinghua, Li, Songyi, Huang, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844554/
https://www.ncbi.nlm.nih.gov/pubmed/28390112
http://dx.doi.org/10.3727/096504017X14912172235777
_version_ 1783644370936791040
author Li, Yinghua
Li, Songyi
Huang, Lili
author_facet Li, Yinghua
Li, Songyi
Huang, Lili
author_sort Li, Yinghua
collection PubMed
description Rap2B, belonging to the Ras superfamily, has been implicated in cancer development and functions as a tumor promoter. However, the role of Rap2B in cervical cancer is unknown. In this study, we investigated the expression pattern and biological functions of Rap2B in cervical cancer. The results showed that Rap2B was overexpressed in cervical cancer tissues and cell lines. Knockdown of Rap2B inhibited the proliferation, migration, and invasion of cervical cancer cells. In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo. We also found that the ERK1/2 signaling pathway is involved in the inhibitory effect of Rap2B knockdown on cervical cancer development. In conclusion, we suggest that Rap2B is an oncogene and may be a promising therapeutic target for cervical cancer.
format Online
Article
Text
id pubmed-7844554
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cognizant Communication Corporation
record_format MEDLINE/PubMed
spelling pubmed-78445542021-02-16 Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway Li, Yinghua Li, Songyi Huang, Lili Oncol Res Article Rap2B, belonging to the Ras superfamily, has been implicated in cancer development and functions as a tumor promoter. However, the role of Rap2B in cervical cancer is unknown. In this study, we investigated the expression pattern and biological functions of Rap2B in cervical cancer. The results showed that Rap2B was overexpressed in cervical cancer tissues and cell lines. Knockdown of Rap2B inhibited the proliferation, migration, and invasion of cervical cancer cells. In addition, our tumorigenesis assay showed that Rap2B knockdown suppressed cervical cancer cell growth and metastasis in vivo. We also found that the ERK1/2 signaling pathway is involved in the inhibitory effect of Rap2B knockdown on cervical cancer development. In conclusion, we suggest that Rap2B is an oncogene and may be a promising therapeutic target for cervical cancer. Cognizant Communication Corporation 2018-01-19 /pmc/articles/PMC7844554/ /pubmed/28390112 http://dx.doi.org/10.3727/096504017X14912172235777 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Li, Yinghua
Li, Songyi
Huang, Lili
Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway
title Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway
title_full Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway
title_fullStr Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway
title_full_unstemmed Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway
title_short Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway
title_sort knockdown of rap2b, a ras superfamily protein, inhibits proliferation, migration, and invasion in cervical cancer cells via regulating the erk1/2 signaling pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844554/
https://www.ncbi.nlm.nih.gov/pubmed/28390112
http://dx.doi.org/10.3727/096504017X14912172235777
work_keys_str_mv AT liyinghua knockdownofrap2barassuperfamilyproteininhibitsproliferationmigrationandinvasionincervicalcancercellsviaregulatingtheerk12signalingpathway
AT lisongyi knockdownofrap2barassuperfamilyproteininhibitsproliferationmigrationandinvasionincervicalcancercellsviaregulatingtheerk12signalingpathway
AT huanglili knockdownofrap2barassuperfamilyproteininhibitsproliferationmigrationandinvasionincervicalcancercellsviaregulatingtheerk12signalingpathway

Ejemplares similares