Cargando…

RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells

RBMS3, a gene encoding a glycine-rich RNA-binding protein, belongs to the family of c-Myc gene single-strand binding proteins (MSSP). Recently, several reports have provided evidence that RBMS3 was deregulated in a diverse range of solid tumors and played a critical role in tumor progression. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yuan, Quan, Lingli, Ling, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844557/
https://www.ncbi.nlm.nih.gov/pubmed/28409548
http://dx.doi.org/10.3727/096504017X14871200709504
_version_ 1783644371650871296
author Yang, Yuan
Quan, Lingli
Ling, Ye
author_facet Yang, Yuan
Quan, Lingli
Ling, Ye
author_sort Yang, Yuan
collection PubMed
description RBMS3, a gene encoding a glycine-rich RNA-binding protein, belongs to the family of c-Myc gene single-strand binding proteins (MSSP). Recently, several reports have provided evidence that RBMS3 was deregulated in a diverse range of solid tumors and played a critical role in tumor progression. However, it remains unclear whether RBMS3 inhibits the progression of human breast cancer. Thus, the aim of this study was to investigate the role of RBMS3 in breast cancer and explore the underlying mechanism in breast cancer progression. Our results showed, for the first time, that the expression of RBMS3 at both the mRNA and protein levels was significantly downregulated in human breast cancer tissues and cell lines. In addition, RBMS3 overexpression dramatically suppressed the proliferation, migration, and invasion of breast cancer cells in vitro and attenuated tumor growth in vivo. Furthermore, we observed that RBMS3 greatly inhibited the protein expression of β-catenin, cyclin D1, and c-Myc in breast cancer cells. In summary, we have shown that RBMS3 inhibited the proliferation and tumorigenesis of breast cancer cells, at least in part, through inactivation of the Wnt/β-catenin signaling pathway. Thus, RBMS3 may be a potential treatment target for breast cancer.
format Online
Article
Text
id pubmed-7844557
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cognizant Communication Corporation
record_format MEDLINE/PubMed
spelling pubmed-78445572021-02-16 RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells Yang, Yuan Quan, Lingli Ling, Ye Oncol Res Article RBMS3, a gene encoding a glycine-rich RNA-binding protein, belongs to the family of c-Myc gene single-strand binding proteins (MSSP). Recently, several reports have provided evidence that RBMS3 was deregulated in a diverse range of solid tumors and played a critical role in tumor progression. However, it remains unclear whether RBMS3 inhibits the progression of human breast cancer. Thus, the aim of this study was to investigate the role of RBMS3 in breast cancer and explore the underlying mechanism in breast cancer progression. Our results showed, for the first time, that the expression of RBMS3 at both the mRNA and protein levels was significantly downregulated in human breast cancer tissues and cell lines. In addition, RBMS3 overexpression dramatically suppressed the proliferation, migration, and invasion of breast cancer cells in vitro and attenuated tumor growth in vivo. Furthermore, we observed that RBMS3 greatly inhibited the protein expression of β-catenin, cyclin D1, and c-Myc in breast cancer cells. In summary, we have shown that RBMS3 inhibited the proliferation and tumorigenesis of breast cancer cells, at least in part, through inactivation of the Wnt/β-catenin signaling pathway. Thus, RBMS3 may be a potential treatment target for breast cancer. Cognizant Communication Corporation 2018-01-19 /pmc/articles/PMC7844557/ /pubmed/28409548 http://dx.doi.org/10.3727/096504017X14871200709504 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Yang, Yuan
Quan, Lingli
Ling, Ye
RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells
title RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells
title_full RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells
title_fullStr RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells
title_full_unstemmed RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells
title_short RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells
title_sort rbms3 inhibits the proliferation and metastasis of breast cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844557/
https://www.ncbi.nlm.nih.gov/pubmed/28409548
http://dx.doi.org/10.3727/096504017X14871200709504
work_keys_str_mv AT yangyuan rbms3inhibitstheproliferationandmetastasisofbreastcancercells
AT quanlingli rbms3inhibitstheproliferationandmetastasisofbreastcancercells
AT lingye rbms3inhibitstheproliferationandmetastasisofbreastcancercells