Cargando…
RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells
RBMS3, a gene encoding a glycine-rich RNA-binding protein, belongs to the family of c-Myc gene single-strand binding proteins (MSSP). Recently, several reports have provided evidence that RBMS3 was deregulated in a diverse range of solid tumors and played a critical role in tumor progression. Howeve...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844557/ https://www.ncbi.nlm.nih.gov/pubmed/28409548 http://dx.doi.org/10.3727/096504017X14871200709504 |
_version_ | 1783644371650871296 |
---|---|
author | Yang, Yuan Quan, Lingli Ling, Ye |
author_facet | Yang, Yuan Quan, Lingli Ling, Ye |
author_sort | Yang, Yuan |
collection | PubMed |
description | RBMS3, a gene encoding a glycine-rich RNA-binding protein, belongs to the family of c-Myc gene single-strand binding proteins (MSSP). Recently, several reports have provided evidence that RBMS3 was deregulated in a diverse range of solid tumors and played a critical role in tumor progression. However, it remains unclear whether RBMS3 inhibits the progression of human breast cancer. Thus, the aim of this study was to investigate the role of RBMS3 in breast cancer and explore the underlying mechanism in breast cancer progression. Our results showed, for the first time, that the expression of RBMS3 at both the mRNA and protein levels was significantly downregulated in human breast cancer tissues and cell lines. In addition, RBMS3 overexpression dramatically suppressed the proliferation, migration, and invasion of breast cancer cells in vitro and attenuated tumor growth in vivo. Furthermore, we observed that RBMS3 greatly inhibited the protein expression of β-catenin, cyclin D1, and c-Myc in breast cancer cells. In summary, we have shown that RBMS3 inhibited the proliferation and tumorigenesis of breast cancer cells, at least in part, through inactivation of the Wnt/β-catenin signaling pathway. Thus, RBMS3 may be a potential treatment target for breast cancer. |
format | Online Article Text |
id | pubmed-7844557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78445572021-02-16 RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells Yang, Yuan Quan, Lingli Ling, Ye Oncol Res Article RBMS3, a gene encoding a glycine-rich RNA-binding protein, belongs to the family of c-Myc gene single-strand binding proteins (MSSP). Recently, several reports have provided evidence that RBMS3 was deregulated in a diverse range of solid tumors and played a critical role in tumor progression. However, it remains unclear whether RBMS3 inhibits the progression of human breast cancer. Thus, the aim of this study was to investigate the role of RBMS3 in breast cancer and explore the underlying mechanism in breast cancer progression. Our results showed, for the first time, that the expression of RBMS3 at both the mRNA and protein levels was significantly downregulated in human breast cancer tissues and cell lines. In addition, RBMS3 overexpression dramatically suppressed the proliferation, migration, and invasion of breast cancer cells in vitro and attenuated tumor growth in vivo. Furthermore, we observed that RBMS3 greatly inhibited the protein expression of β-catenin, cyclin D1, and c-Myc in breast cancer cells. In summary, we have shown that RBMS3 inhibited the proliferation and tumorigenesis of breast cancer cells, at least in part, through inactivation of the Wnt/β-catenin signaling pathway. Thus, RBMS3 may be a potential treatment target for breast cancer. Cognizant Communication Corporation 2018-01-19 /pmc/articles/PMC7844557/ /pubmed/28409548 http://dx.doi.org/10.3727/096504017X14871200709504 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Article Yang, Yuan Quan, Lingli Ling, Ye RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells |
title | RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells |
title_full | RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells |
title_fullStr | RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells |
title_full_unstemmed | RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells |
title_short | RBMS3 Inhibits the Proliferation and Metastasis of Breast Cancer Cells |
title_sort | rbms3 inhibits the proliferation and metastasis of breast cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844557/ https://www.ncbi.nlm.nih.gov/pubmed/28409548 http://dx.doi.org/10.3727/096504017X14871200709504 |
work_keys_str_mv | AT yangyuan rbms3inhibitstheproliferationandmetastasisofbreastcancercells AT quanlingli rbms3inhibitstheproliferationandmetastasisofbreastcancercells AT lingye rbms3inhibitstheproliferationandmetastasisofbreastcancercells |