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MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor

Dysregulated microRNA (miRNA) expression is involved in the occurrence and development of colorectal cancer (CRC) through the regulation of various important physiological events. Hence, miRNAs may be used as effective targets for CRC treatment; however, this hypothesis warrants further investigatio...

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Detalles Bibliográficos
Autores principales: He, Saifei, Wang, Guangdong, Ni, Jing, Zhuang, Juhua, Zhuang, Suiliang, Wang, Guoyu, Ye, Ying, Xia, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844599/
https://www.ncbi.nlm.nih.gov/pubmed/29321086
http://dx.doi.org/10.3727/096504018X15154094331876
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author He, Saifei
Wang, Guangdong
Ni, Jing
Zhuang, Juhua
Zhuang, Suiliang
Wang, Guoyu
Ye, Ying
Xia, Wei
author_facet He, Saifei
Wang, Guangdong
Ni, Jing
Zhuang, Juhua
Zhuang, Suiliang
Wang, Guoyu
Ye, Ying
Xia, Wei
author_sort He, Saifei
collection PubMed
description Dysregulated microRNA (miRNA) expression is involved in the occurrence and development of colorectal cancer (CRC) through the regulation of various important physiological events. Hence, miRNAs may be used as effective targets for CRC treatment; however, this hypothesis warrants further investigation. miRNA-511 (miR-511) plays vital roles in the progression of different tumor types. However, the expression, exact role, and the mechanisms underlying the regulation of colorectal carcinogenesis and progression by miR-511 remain poorly understood. This study presents that miR-511 expression was decreased in CRC tissues and cell lines compared with that in adjacent nonneoplastic tissues and normal human colon epithelium cell lines, respectively. The enforced expression of miR-511 in CRC cells significantly reduced cell proliferation and invasion. Hepatoma-derived growth factor (HDGF) was mechanically validated as a direct target of miR-511 in CRC. Furthermore, miR-511 was negatively associated with HDGF in CRC tissues. The restored HDGF expression can abrogate the tumor-suppressive roles of miR-511 in CRC cells. More importantly, miR-511 overexpression suppressed the PI3K/AKT signaling pathway in CRC. These results suggest that miR-511 can potentially serve as a therapeutic target for the therapy of patients with CRC.
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spelling pubmed-78445992021-02-16 MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor He, Saifei Wang, Guangdong Ni, Jing Zhuang, Juhua Zhuang, Suiliang Wang, Guoyu Ye, Ying Xia, Wei Oncol Res Article Dysregulated microRNA (miRNA) expression is involved in the occurrence and development of colorectal cancer (CRC) through the regulation of various important physiological events. Hence, miRNAs may be used as effective targets for CRC treatment; however, this hypothesis warrants further investigation. miRNA-511 (miR-511) plays vital roles in the progression of different tumor types. However, the expression, exact role, and the mechanisms underlying the regulation of colorectal carcinogenesis and progression by miR-511 remain poorly understood. This study presents that miR-511 expression was decreased in CRC tissues and cell lines compared with that in adjacent nonneoplastic tissues and normal human colon epithelium cell lines, respectively. The enforced expression of miR-511 in CRC cells significantly reduced cell proliferation and invasion. Hepatoma-derived growth factor (HDGF) was mechanically validated as a direct target of miR-511 in CRC. Furthermore, miR-511 was negatively associated with HDGF in CRC tissues. The restored HDGF expression can abrogate the tumor-suppressive roles of miR-511 in CRC cells. More importantly, miR-511 overexpression suppressed the PI3K/AKT signaling pathway in CRC. These results suggest that miR-511 can potentially serve as a therapeutic target for the therapy of patients with CRC. Cognizant Communication Corporation 2018-10-17 /pmc/articles/PMC7844599/ /pubmed/29321086 http://dx.doi.org/10.3727/096504018X15154094331876 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
He, Saifei
Wang, Guangdong
Ni, Jing
Zhuang, Juhua
Zhuang, Suiliang
Wang, Guoyu
Ye, Ying
Xia, Wei
MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor
title MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor
title_full MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor
title_fullStr MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor
title_full_unstemmed MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor
title_short MicroRNA-511 Inhibits Cellular Proliferation and Invasion in Colorectal Cancer by Directly Targeting Hepatoma-Derived Growth Factor
title_sort microrna-511 inhibits cellular proliferation and invasion in colorectal cancer by directly targeting hepatoma-derived growth factor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844599/
https://www.ncbi.nlm.nih.gov/pubmed/29321086
http://dx.doi.org/10.3727/096504018X15154094331876
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