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Aberrant lncRNA Expression in Multiple Myeloma
Multiple myeloma (MM), a type of malignant tumor, is characterized by dysplasia of clonal plasma cells in the bone marrow. People with MM will have damaged organs or tissues due to secretion of large amounts of monoclonal immunoglobulin or fragments (M protein). Despite improved survivability by nov...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844626/ https://www.ncbi.nlm.nih.gov/pubmed/29212572 http://dx.doi.org/10.3727/096504017X15123872205507 |
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author | Meng, Hui Han, Lei Hong, Chun Ding, Jinya Huang, Qianchuan |
author_facet | Meng, Hui Han, Lei Hong, Chun Ding, Jinya Huang, Qianchuan |
author_sort | Meng, Hui |
collection | PubMed |
description | Multiple myeloma (MM), a type of malignant tumor, is characterized by dysplasia of clonal plasma cells in the bone marrow. People with MM will have damaged organs or tissues due to secretion of large amounts of monoclonal immunoglobulin or fragments (M protein). Despite improved survivability by novel treatment strategies over the last decade, MM is still incurable by current therapies. Long noncoding RNAs (lncRNAs), with length of more than 200 nucleotides, have been reported to act as important regulators in many diseases, including MM. Recent studies have reported aberrant lncRNA expression in MM; these dysregulated lncRNAs can play oncogenic and/or tumor-suppressive roles in the development and progression of MM. In this article, we present a general overview on the role of lncRNAs in MM pathogenesis and discuss their potential as prognostic biomarkers and targets for treatment. |
format | Online Article Text |
id | pubmed-7844626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78446262021-02-16 Aberrant lncRNA Expression in Multiple Myeloma Meng, Hui Han, Lei Hong, Chun Ding, Jinya Huang, Qianchuan Oncol Res Review Multiple myeloma (MM), a type of malignant tumor, is characterized by dysplasia of clonal plasma cells in the bone marrow. People with MM will have damaged organs or tissues due to secretion of large amounts of monoclonal immunoglobulin or fragments (M protein). Despite improved survivability by novel treatment strategies over the last decade, MM is still incurable by current therapies. Long noncoding RNAs (lncRNAs), with length of more than 200 nucleotides, have been reported to act as important regulators in many diseases, including MM. Recent studies have reported aberrant lncRNA expression in MM; these dysregulated lncRNAs can play oncogenic and/or tumor-suppressive roles in the development and progression of MM. In this article, we present a general overview on the role of lncRNAs in MM pathogenesis and discuss their potential as prognostic biomarkers and targets for treatment. Cognizant Communication Corporation 2018-06-11 /pmc/articles/PMC7844626/ /pubmed/29212572 http://dx.doi.org/10.3727/096504017X15123872205507 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Review Meng, Hui Han, Lei Hong, Chun Ding, Jinya Huang, Qianchuan Aberrant lncRNA Expression in Multiple Myeloma |
title | Aberrant lncRNA Expression in Multiple Myeloma |
title_full | Aberrant lncRNA Expression in Multiple Myeloma |
title_fullStr | Aberrant lncRNA Expression in Multiple Myeloma |
title_full_unstemmed | Aberrant lncRNA Expression in Multiple Myeloma |
title_short | Aberrant lncRNA Expression in Multiple Myeloma |
title_sort | aberrant lncrna expression in multiple myeloma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844626/ https://www.ncbi.nlm.nih.gov/pubmed/29212572 http://dx.doi.org/10.3727/096504017X15123872205507 |
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