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MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R
The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cognizant Communication Corporation
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844686/ https://www.ncbi.nlm.nih.gov/pubmed/29422116 http://dx.doi.org/10.3727/096504018X15178798885361 |
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author | Zou, Zeng Cheng Dai, Min Huang, Zeng Yin Lu, Yi Xie, He Ping Li, Yi Fang Li, Yue Tan, Ying Wang, Feng Lin |
author_facet | Zou, Zeng Cheng Dai, Min Huang, Zeng Yin Lu, Yi Xie, He Ping Li, Yi Fang Li, Yue Tan, Ying Wang, Feng Lin |
author_sort | Zou, Zeng Cheng |
collection | PubMed |
description | The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R expression. |
format | Online Article Text |
id | pubmed-7844686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cognizant Communication Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-78446862021-02-16 MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R Zou, Zeng Cheng Dai, Min Huang, Zeng Yin Lu, Yi Xie, He Ping Li, Yi Fang Li, Yue Tan, Ying Wang, Feng Lin Oncol Res Article The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R expression. Cognizant Communication Corporation 2018-10-17 /pmc/articles/PMC7844686/ /pubmed/29422116 http://dx.doi.org/10.3727/096504018X15178798885361 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License. |
spellingShingle | Article Zou, Zeng Cheng Dai, Min Huang, Zeng Yin Lu, Yi Xie, He Ping Li, Yi Fang Li, Yue Tan, Ying Wang, Feng Lin MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R |
title | MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R |
title_full | MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R |
title_fullStr | MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R |
title_full_unstemmed | MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R |
title_short | MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R |
title_sort | microrna-139-3p suppresses tumor growth and metastasis in hepatocellular carcinoma by repressing anxa2r |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844686/ https://www.ncbi.nlm.nih.gov/pubmed/29422116 http://dx.doi.org/10.3727/096504018X15178798885361 |
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