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MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R

The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in...

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Autores principales: Zou, Zeng Cheng, Dai, Min, Huang, Zeng Yin, Lu, Yi, Xie, He Ping, Li, Yi Fang, Li, Yue, Tan, Ying, Wang, Feng Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844686/
https://www.ncbi.nlm.nih.gov/pubmed/29422116
http://dx.doi.org/10.3727/096504018X15178798885361
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author Zou, Zeng Cheng
Dai, Min
Huang, Zeng Yin
Lu, Yi
Xie, He Ping
Li, Yi Fang
Li, Yue
Tan, Ying
Wang, Feng Lin
author_facet Zou, Zeng Cheng
Dai, Min
Huang, Zeng Yin
Lu, Yi
Xie, He Ping
Li, Yi Fang
Li, Yue
Tan, Ying
Wang, Feng Lin
author_sort Zou, Zeng Cheng
collection PubMed
description The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R expression.
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spelling pubmed-78446862021-02-16 MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R Zou, Zeng Cheng Dai, Min Huang, Zeng Yin Lu, Yi Xie, He Ping Li, Yi Fang Li, Yue Tan, Ying Wang, Feng Lin Oncol Res Article The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R expression. Cognizant Communication Corporation 2018-10-17 /pmc/articles/PMC7844686/ /pubmed/29422116 http://dx.doi.org/10.3727/096504018X15178798885361 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Zou, Zeng Cheng
Dai, Min
Huang, Zeng Yin
Lu, Yi
Xie, He Ping
Li, Yi Fang
Li, Yue
Tan, Ying
Wang, Feng Lin
MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R
title MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R
title_full MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R
title_fullStr MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R
title_full_unstemmed MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R
title_short MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R
title_sort microrna-139-3p suppresses tumor growth and metastasis in hepatocellular carcinoma by repressing anxa2r
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844686/
https://www.ncbi.nlm.nih.gov/pubmed/29422116
http://dx.doi.org/10.3727/096504018X15178798885361
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