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Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner

Recent studies revealed that emodin extracted from Chinese herbs exhibits an anticancer effect on different cancer types, including colon cancer. However, the mechanism is not well understood. In our study, we confirmed that emodin treatment inhibited cell viability and induced apoptosis in colon ca...

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Detalles Bibliográficos
Autores principales: Wang, Yuanyuan, Luo, Qin, He, Xianlu, Wei, He, Wang, Ting, Shao, Jichun, Jiang, Xinni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844792/
https://www.ncbi.nlm.nih.gov/pubmed/28762328
http://dx.doi.org/10.3727/096504017X15009419625178
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author Wang, Yuanyuan
Luo, Qin
He, Xianlu
Wei, He
Wang, Ting
Shao, Jichun
Jiang, Xinni
author_facet Wang, Yuanyuan
Luo, Qin
He, Xianlu
Wei, He
Wang, Ting
Shao, Jichun
Jiang, Xinni
author_sort Wang, Yuanyuan
collection PubMed
description Recent studies revealed that emodin extracted from Chinese herbs exhibits an anticancer effect on different cancer types, including colon cancer. However, the mechanism is not well understood. In our study, we confirmed that emodin treatment inhibited cell viability and induced apoptosis in colon cancer cells. Further experiments found that emodin was also able to induce autophagy, which is indispensible for apoptosis induced by emodin. More interestingly, emodin treatment also results in mitochondrial dysfunction and ROS accumulation in colon cancer cells. Finally, we stressed that ROS accumulation is essential for autophagy and apoptosis induced by emodin. In conclusion, emodin induces apoptosis in colon cancer cells through induction of autophagy, during which ROS generation is of the essence. Our findings improve understanding of emodin’s effect on colon cancer suppression and provide a new theoretical basis for colon cancer therapy.
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spelling pubmed-78447922021-02-16 Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner Wang, Yuanyuan Luo, Qin He, Xianlu Wei, He Wang, Ting Shao, Jichun Jiang, Xinni Oncol Res Article Recent studies revealed that emodin extracted from Chinese herbs exhibits an anticancer effect on different cancer types, including colon cancer. However, the mechanism is not well understood. In our study, we confirmed that emodin treatment inhibited cell viability and induced apoptosis in colon cancer cells. Further experiments found that emodin was also able to induce autophagy, which is indispensible for apoptosis induced by emodin. More interestingly, emodin treatment also results in mitochondrial dysfunction and ROS accumulation in colon cancer cells. Finally, we stressed that ROS accumulation is essential for autophagy and apoptosis induced by emodin. In conclusion, emodin induces apoptosis in colon cancer cells through induction of autophagy, during which ROS generation is of the essence. Our findings improve understanding of emodin’s effect on colon cancer suppression and provide a new theoretical basis for colon cancer therapy. Cognizant Communication Corporation 2018-07-05 /pmc/articles/PMC7844792/ /pubmed/28762328 http://dx.doi.org/10.3727/096504017X15009419625178 Text en Copyright © 2018 Cognizant, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.
spellingShingle Article
Wang, Yuanyuan
Luo, Qin
He, Xianlu
Wei, He
Wang, Ting
Shao, Jichun
Jiang, Xinni
Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner
title Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner
title_full Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner
title_fullStr Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner
title_full_unstemmed Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner
title_short Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner
title_sort emodin induces apoptosis of colon cancer cells via induction of autophagy in a ros-dependent manner
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844792/
https://www.ncbi.nlm.nih.gov/pubmed/28762328
http://dx.doi.org/10.3727/096504017X15009419625178
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