Cargando…

Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection

Detalles Bibliográficos
Autores principales:	Kalra, Rajkumar Singh, Kandimalla, Ramesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Research Highlight
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844799/ https://www.ncbi.nlm.nih.gov/pubmed/33514685 http://dx.doi.org/10.1038/s41392-021-00470-1

Ejemplares similares

Spike-heparan sulfate interactions in SARS-CoV-2 infection
por: Kearns, Fiona L., et al.
Publicado: (2022)

Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions
por: Kwon, Paul S., et al.
Publicado: (2023)

On the Selectivity of Heparan Sulfate Recognition by SARS-CoV-2 Spike Glycoprotein
por: Chittum, John E., et al.
Publicado: (2021)

Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate
por: Tiwari, Vaibhav, et al.
Publicado: (2020)

Probing key interactions between SARS-CoV-2 spike and heparan sulfate
por: Kearns, Fiona L., et al.
Publicado: (2022)

Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus
por: Yan, Lufeng, et al.
Publicado: (2021)

SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate
por: Zheng, Yi, et al.
Publicado: (2021)

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
por: Guimond, Scott E., et al.
Publicado: (2022)

Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection
por: Zhang, Qi, et al.
Publicado: (2022)

The SARS-CoV-2 spike protein: balancing stability and infectivity
por: Berger, Imre, et al.
Publicado: (2020)

Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 binding
por: Scheiblhofer, Sandra, et al.
Publicado: (2021)

SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings
por: Kalra, Rajkumar Singh, et al.
Publicado: (2020)

New strategy for COVID-19 vaccination: targeting the receptor-binding domain of the SARS-CoV-2 spike protein
por: Wang, Junzhi
Publicado: (2020)

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
por: Prieto-Fernández, Endika, et al.
Publicado: (2021)

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
por: Clausen, Thomas Mandel, et al.
Publicado: (2020)

Spike residue 403 affects binding of coronavirus spikes to human ACE2
por: Zech, Fabian, et al.
Publicado: (2021)

Omicron spike protein: a clue for viral entry and immune evasion
por: Behrens, G. M. N., et al.
Publicado: (2022)

SARS-CoV-2 spike and ACE2 entanglement-like binding
por: Pregnolato, Massimo, et al.
Publicado: (2023)

Heparan sulfates and heparan sulfate binding proteins in sepsis
por: Liao, Yi-En, et al.
Publicado: (2023)

SARS-CoV-2 spike protein: flexibility as a new target for fighting infection
por: Pierri, Ciro Leonardo
Publicado: (2020)

Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant
por: Odak, Ivan, et al.
Publicado: (2022)

SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies
por: Yang, Yang, et al.
Publicado: (2021)

Revealing the Mechanism of SARS-CoV-2 Spike Protein Binding With ACE2
Publicado: (2020)

Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike
por: Wrobel, Antoni G.
Publicado: (2023)

Variations in cell-surface ACE2 levels alter direct binding of SARS-CoV-2 Spike protein and viral infectivity: Implications for measuring Spike protein interactions with animal ACE2 orthologs
por: Kazemi, Soheila, et al.
Publicado: (2021)

Variations in Cell Surface ACE2 Levels Alter Direct Binding of SARS-CoV-2 Spike Protein and Viral Infectivity: Implications for Measuring Spike Protein Interactions with Animal ACE2 Orthologs
por: Kazemi, Soheila, et al.
Publicado: (2022)

Spiking the MERS-coronavirus receptor
por: Bosch, Berend Jan, et al.
Publicado: (2013)

Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants
por: Ou, Junxian, et al.
Publicado: (2022)

SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation
por: Yu, Shi, et al.
Publicado: (2021)

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike
por: Mehdipour, Ahmad Reza, et al.
Publicado: (2021)

Perturbation of ACE2 Structural Ensembles by SARS-CoV-2 Spike Protein Binding
por: Uyar, Arzu, et al.
Publicado: (2021)

SARS-CoV-2 spike binding to ACE2 is stronger and longer ranged with glycans
por: Huang, Yihan, et al.
Publicado: (2022)

Identifying Hotspots in Binding of SARS-CoV-2 Spike Glycoprotein and Human ACE2
por: Mendis, Jenny, et al.
Publicado: (2021)

SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET
por: Cecon, Erika, et al.
Publicado: (2022)

Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding
por: Thakur, Shivani, et al.
Publicado: (2023)

Adapt or perish: SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain
por: Ribes, Marta, et al.
Publicado: (2021)

Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer
por: Yue, Jingwen, et al.
Publicado: (2021)

Sulfated polysaccharides act as baits to interfere with the binding of the spike protein (SARS-CoV-2) to the ACE2 receptor and can be administered through food
por: Barbosa, Jhonatas Rodrigues, et al.
Publicado: (2023)

Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2
por: Edwards, Michael J., et al.
Publicado: (2020)

The ACE2-binding interface of SARS-CoV-2 Spike inherently deflects immune recognition
por: Hattori, Takamitsu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2v1lhucp7vunqtaqu1ma5hjfio