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Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity

Background: Oncogenic transformation is associated with elevated oxidative stress that promotes tumor progression but also renders cancer cells vulnerable to further oxidative insult. Agents that stimulate ROS generation or suppress antioxidant systems can drive oxidative pressure to toxic levels se...

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Detalles Bibliográficos
Autores principales:	Chang, Mingxin, Wang, Hongge, Niu, Jiajing, Song, Yan, Zou, Zhihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844861/ https://www.ncbi.nlm.nih.gov/pubmed/33519476 http://dx.doi.org/10.3389/fphar.2020.610205

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