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Optimal treatment for penile verrucous carcinoma: a systematic literature review
Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are ne...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844965/ https://www.ncbi.nlm.nih.gov/pubmed/33514369 http://dx.doi.org/10.1186/s12894-020-00777-1 |
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author | Jo, Dong In Han, Song Hyun Kim, Soon Heum Kim, Hye Young Chung, Hong Kim, Hong Sup |
author_facet | Jo, Dong In Han, Song Hyun Kim, Soon Heum Kim, Hye Young Chung, Hong Kim, Hong Sup |
author_sort | Jo, Dong In |
collection | PubMed |
description | Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are needed. Methods: To identify the up-to-date general biological behavior, diagnosis, and treatment trends, we searched PubMed using the keyword “penile verrucous carcinoma” without restrictions on publication date. Results: Current treatments for penile verrucous carcinoma include wide surgical excision, seldom preventive lymphadenectomy, and conservative chemotherapy without surgery or local excision with safe margins. Despite the advent of partial penectomy to minimally impact function and aesthetics, affected patients experience psychosexual problems. Local excision can be used to save the penile shaft and glans penis without preventive lymphadenectomy or adjuvant therapy and can achieve good clinical prognosis with rare recurrence. Conclusions: To preserve the functional and cosmetic aspects, we recommend local excision, especially for tumors measuring < 3 cm and classified as stage T1 according to the 2016 tumor node metastasis clinical and pathological classification for penile cancer. |
format | Online Article Text |
id | pubmed-7844965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78449652021-02-01 Optimal treatment for penile verrucous carcinoma: a systematic literature review Jo, Dong In Han, Song Hyun Kim, Soon Heum Kim, Hye Young Chung, Hong Kim, Hong Sup BMC Urol Research Article Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are needed. Methods: To identify the up-to-date general biological behavior, diagnosis, and treatment trends, we searched PubMed using the keyword “penile verrucous carcinoma” without restrictions on publication date. Results: Current treatments for penile verrucous carcinoma include wide surgical excision, seldom preventive lymphadenectomy, and conservative chemotherapy without surgery or local excision with safe margins. Despite the advent of partial penectomy to minimally impact function and aesthetics, affected patients experience psychosexual problems. Local excision can be used to save the penile shaft and glans penis without preventive lymphadenectomy or adjuvant therapy and can achieve good clinical prognosis with rare recurrence. Conclusions: To preserve the functional and cosmetic aspects, we recommend local excision, especially for tumors measuring < 3 cm and classified as stage T1 according to the 2016 tumor node metastasis clinical and pathological classification for penile cancer. BioMed Central 2021-01-29 /pmc/articles/PMC7844965/ /pubmed/33514369 http://dx.doi.org/10.1186/s12894-020-00777-1 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Jo, Dong In Han, Song Hyun Kim, Soon Heum Kim, Hye Young Chung, Hong Kim, Hong Sup Optimal treatment for penile verrucous carcinoma: a systematic literature review |
title | Optimal treatment for penile verrucous carcinoma: a systematic literature review |
title_full | Optimal treatment for penile verrucous carcinoma: a systematic literature review |
title_fullStr | Optimal treatment for penile verrucous carcinoma: a systematic literature review |
title_full_unstemmed | Optimal treatment for penile verrucous carcinoma: a systematic literature review |
title_short | Optimal treatment for penile verrucous carcinoma: a systematic literature review |
title_sort | optimal treatment for penile verrucous carcinoma: a systematic literature review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844965/ https://www.ncbi.nlm.nih.gov/pubmed/33514369 http://dx.doi.org/10.1186/s12894-020-00777-1 |
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