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Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease

BACKGROUND: Multimerization is a key process in prion-like disorders such as Alzheimer’s disease (AD), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis. AT8-immunohistochemistry for hyperphosphorylated tau is currently used for the diagnosis and staging of tau patho...

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Detalles Bibliográficos
Autores principales:	Bengoa-Vergniory, Nora, Velentza-Almpani, Elisavet, Silva, Ana Maria, Scott, Connor, Vargas-Caballero, Mariana, Sastre, Magdalena, Wade-Martins, Richard, Alegre-Abarrategui, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844979/ https://www.ncbi.nlm.nih.gov/pubmed/33509301 http://dx.doi.org/10.1186/s40478-020-01117-y

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