Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

BACKGROUND: B7-H3, an immune-checkpoint molecule and a transmembrane protein, is overexpressed in non-small cell lung cancer (NSCLC), making it an attractive therapeutic target. Here, we aimed to systematically evaluate the value of B7-H3 as a target in NSCLC via T cells expressing B7-H3-specific ch...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Yang, Shuo, Cao, Bihui, Zhou, Guangyu, Zhang, Fengjuan, Wang, Yuan, Wang, Rixin, Zhu, Lipeng, Meng, Ya, Hu, Cong, Liang, Hui, Lin, Xu, Zhu, Kangshun, Chen, Guokai, Luo, Kathy Qian, Di, Lijun, Zhao, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844995/
https://www.ncbi.nlm.nih.gov/pubmed/33514401
http://dx.doi.org/10.1186/s13045-020-01024-8

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