Cargando…

Safety of natural anthraquinone emodin: an assessment in mice

BACKGROUND: Emodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surrounding its potential toxicity. The primary purpose of this study was to uncover a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sougiannis, Alexander T., Enos, Reilly T., VanderVeen, Brandon N., Velazquez, Kandy T., Kelly, Brittany, McDonald, Sierra, Cotham, William, Chatzistamou, Ioulia, Nagarkatti, Mitzi, Fan, Daping, Murphy, E. Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845031/ https://www.ncbi.nlm.nih.gov/pubmed/33509280 http://dx.doi.org/10.1186/s40360-021-00474-1

Ejemplares similares

Therapeutic Potential of Emodin for Gastrointestinal Cancers
por: McDonald, Sierra J., et al.
Publicado: (2022)

Emodin reduces surgical wounding‐accelerated tumor growth and metastasis via macrophage suppression in a murine triple‐negative breast cancer model
por: McDonald, Sierra J., et al.
Publicado: (2023)

Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice
por: Velázquez, Kandy T, et al.
Publicado: (2019)

Sub-chronic oral toxicity screening of quercetin in mice
por: Cunningham, Patrice, et al.
Publicado: (2022)

The Acute Effects of 5 Fluorouracil on Skeletal Muscle Resident and Infiltrating Immune Cells in Mice
por: VanderVeen, Brandon N., et al.
Publicado: (2020)

High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages
por: Bader, Jackie, et al.
Publicado: (2020)

Surgical wounding enhances pro‐tumor macrophage responses and accelerates tumor growth and lung metastasis in a triple negative breast cancer mouse model
por: McDonald, Sierra J., et al.
Publicado: (2022)

Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice
por: VanderVeen, Brandon N., et al.
Publicado: (2022)

Quercetin Improved Muscle Mass and Mitochondrial Content in a Murine Model of Cancer and Chemotherapy-Induced Cachexia
por: VanderVeen, Brandon N., et al.
Publicado: (2022)

A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice
por: Enos, Reilly T., et al.
Publicado: (2016)

Effect of TCDD exposure in adult female and male mice on the expression of miRNA in the ovaries and testes and associated reproductive functions
por: Hall, Alina, et al.
Publicado: (2023)

miR155 deficiency aggravates high‐fat diet‐induced adipose tissue fibrosis in male mice
por: Velázquez, Kandy T., et al.
Publicado: (2017)

Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity
por: Mehrpouya-Bahrami, Pegah, et al.
Publicado: (2017)

An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes
por: Martorell, Miquel, et al.
Publicado: (2021)

Role of MCP-1 on Inflammatory Processes and Metabolic Dysfunction Following High-Fat Feedings in the FVB/N Strain
por: Cranford, Taryn L., et al.
Publicado: (2015)

Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized mice
por: Unger, Christian A., et al.
Publicado: (2022)

Platelet status in cancer cachexia progression in Apc(Min/+) mice
por: Cunningham, Patrice, et al.
Publicado: (2023)

Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production
por: Becker, William, et al.
Publicado: (2020)

Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia
por: Li, Rong-Rong, et al.
Publicado: (2019)

Immune and microRNA responses to Helicobacter muridarum infection and indole-3-carbinol during colitis
por: Alkarkoushi, Rasha Raheem, et al.
Publicado: (2020)

Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in Apc(Min/+) mice
por: Narsale, Aditi A., et al.
Publicado: (2016)

Ojeok-san ameliorates visceral and somatic nociception in a mouse model of colitis induced colorectal cancer
por: Cunningham, Patrice, et al.
Publicado: (2022)

Acute Administration of Ojeok-san Ameliorates Pain-like Behaviors in Pre-Clinical Models of Inflammatory Bowel Diseases
por: Patton, Emma A., et al.
Publicado: (2023)

Antimicrobial structure activity relationship of five anthraquinones of emodine type isolated from Vismia laurentii
por: Kemegne, Gislaine Aurelie, et al.
Publicado: (2017)

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
por: Stompor-Gorący, Monika
Publicado: (2021)

The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia
por: VanderVeen, Brandon N., et al.
Publicado: (2020)

Emodin, a Natural Anthraquinone, Increases Uric Acid Excretion in Rats with Potassium Oxonate-Induced Hyperuricemia
por: Hou, Shen-Wei, et al.
Publicado: (2023)

Aloe-Emodin Derivative, an Anthraquinone Compound, Attenuates Pyroptosis by Targeting NLRP3 Inflammasome in Diabetic Cardiomyopathy
por: Hu, Yingying, et al.
Publicado: (2023)

Regulation of Skeletal Muscle DRP-1 and FIS-1 Protein Expression by IL-6 Signaling
por: Fix, Dennis K., et al.
Publicado: (2019)

Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
por: Kauroo, Shahin, et al.
Publicado: (2021)

Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel
por: Mohammed, Ahmed Dawood, et al.
Publicado: (2022)

The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo
por: Xiong, Hai-Rong, et al.
Publicado: (2011)

The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
por: Zhang, Qing, et al.
Publicado: (2022)

Reducing the Dietary Omega-6:Omega-3 Utilizing α-Linolenic Acid; Not a Sufficient Therapy for Attenuating High-Fat-Diet-Induced Obesity Development Nor Related Detrimental Metabolic and Adipose Tissue Inflammatory Outcomes
por: Enos, Reilly T., et al.
Publicado: (2014)

Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation
por: VanderVeen, Brandon N., et al.
Publicado: (2017)

Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation
por: Liu, Qing, et al.
Publicado: (2020)

Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats
por: Tzeng, Thing-Fong, et al.
Publicado: (2012)

Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials
por: Fairman, Ciaran M., et al.
Publicado: (2022)

Anthraquinone Emodin Inhibits Tumor Necrosis Factor Alpha-Induced Calcification of Human Aortic Valve Interstitial Cells via the NF-κB Pathway
por: Xu, Kang, et al.
Publicado: (2018)

Kruppel like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells
por: Ou, Lingling, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_viss4fulkh2nshh575bnm9gdme