Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis

Toxoplasmosis, a protozoan infection caused by Toxoplasma gondii, is estimated to affect around 2.5 billion people worldwide. Nevertheless, the side effects of drugs combined with the long period of therapy usually result in discontinuation of the treatment. New therapies should be developed by expl...

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Detalles Bibliográficos
Autores principales: Ferrarini, Mariana Galvão, Nisimura, Lindice Mitie, Girard, Richard Marcel Bruno Moreira, Alencar, Mayke Bezerra, Fragoso, Mariana Sayuri Ishikawa, Araújo-Silva, Carlla Assis, Veiga, Alan de Almeida, Abud, Ana Paula Ressetti, Nardelli, Sheila Cristina, Vommaro, Rossiane C., Silber, Ariel Mariano, France-Sagot, Marie, Ávila, Andréa Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845590/
https://www.ncbi.nlm.nih.gov/pubmed/33408226
http://dx.doi.org/10.1128/mSphere.01002-20

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