Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) evolve to generate environmentally adapted biofilm communities, leading to increased patient morbidity and mortality. OligoG CF-5/20, a low-molecular-weight inhaled alginate oligomer therapy, is currently in phase IIb/III clinica...

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Detalles Bibliográficos
Autores principales: Oakley, Juliette L., Weiser, Rebecca, Powell, Lydia C., Forton, Julian, Mahenthiralingam, Eshwar, Rye, Philip D., Hill, Katja E., Thomas, David W., Pritchard, Manon F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845618/
https://www.ncbi.nlm.nih.gov/pubmed/33472983
http://dx.doi.org/10.1128/mSphere.01216-20

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