5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium

5-Aminosalicylic acid (5-ASA), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is a widely used first-line medication for the treatment of ulcerative colitis, but its anti-inflammatory mechanism is not fully resolved. Here, we show that 5-ASA ameliorates colitis in dextran sulfa...

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Detalles Bibliográficos
Autores principales: Cevallos, Stephanie A., Lee, Jee-Yon, Velazquez, Eric M., Foegeding, Nora J., Shelton, Catherine D., Tiffany, Connor R., Parry, Beau H., Stull-Lane, Annica R., Olsan, Erin E., Savage, Hannah P., Nguyen, Henry, Ghanaat, Star S., Byndloss, Austin J., Agu, Ilechukwu O., Tsolis, Renée M., Byndloss, Mariana X., Bäumler, Andreas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845635/
https://www.ncbi.nlm.nih.gov/pubmed/33468700
http://dx.doi.org/10.1128/mBio.03227-20

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