Physiologically-Based Pharmacokinetic-Pharmacodynamics Model Characterizing CYP2C19 Polymorphisms to Predict Clopidogrel Pharmacokinetics and Its Anti-Platelet Aggregation Effect Following Oral Administration to Coronary Artery Disease Patients With or Without Diabetes

Background and Objective: Clopidogrel (CLOP) is commonly used in coronary artery disease (CAD) patients with or without diabetes (DM), but these patients often suffer CLOP resistance, especially those with diabetes. This study was aimed to develop a physiologically-based pharmacokinetic-pharmacodyna...

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Detalles Bibliográficos
Autores principales: Xu, Ru-jun, Kong, Wei-min, An, Xiao-fei, Zou, Jian-jun, Liu, Li, Liu, Xiao-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845657/
https://www.ncbi.nlm.nih.gov/pubmed/33519456
http://dx.doi.org/10.3389/fphar.2020.593982

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