Cargando…

Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA and host cell factors, respectively. We tested both types of compounds against two types of coronaviruses, to co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Cheng-Wei, Lee, Yue-Zhi, Hsu, Hsing-Yu, Jan, Jia-Tsrong, Lin, Yi-Ling, Chang, Sui-Yuan, Peng, Tzu-Ting, Yang, Ruey-Bing, Liang, Jian-Jong, Liao, Chun-Che, Chao, Tai-Ling, Pang, Yu-Hau, Kao, Han-Chieh, Huang, Wen-Zheng, Lin, Jiunn-Horng, Chang, Chun-Ping, Niu, Guang-Hao, Wu, Szu-Huei, Sytwu, Huey-Kang, Chen, Chiung-Tong, Lee, Shiow-Ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845692/ https://www.ncbi.nlm.nih.gov/pubmed/33519469 http://dx.doi.org/10.3389/fphar.2020.606097

Ejemplares similares

The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b
por: Lee, Yue-Zhi, et al.
Publicado: (2022)

Correction: Lee et al. The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Pharmaceutics 2022, 14, 1511
por: Lee, Yue-Zhi, et al.
Publicado: (2023)

Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity
por: Yang, Cheng-Wei, et al.
Publicado: (2017)

Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2
por: Hsu, Hsing-Yu, et al.
Publicado: (2021)

Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na(+)/K(+)-ATPase independent proteolysis
por: Yang, Cheng-Wei, et al.
Publicado: (2020)

Repurposing old drugs as antiviral agents for coronaviruses
por: Yang, Cheng-Wei, et al.
Publicado: (2020)

Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus
por: Yang, Cheng-Wei, et al.
Publicado: (2010)

The cardenolide ouabain suppresses coronaviral replication via augmenting a Na(+)/K(+)-ATPase-dependent PI3K_PDK1 axis signaling
por: Yang, Cheng-Wei, et al.
Publicado: (2018)

Erratum to “Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na(+)/K(+)-ATPase independent proteolysis” [Biochem. Pharmacol. 180 (2020) 114122]
por: Yang, Cheng-Wei, et al.
Publicado: (2020)

Artificial intelligence approach fighting COVID-19 with repurposing drugs
por: Ke, Yi-Yu, et al.
Publicado: (2020)

Tylophorine: Sources, Properties, Applications and Biotechnological Production
por: Cyriac, Angeline, et al.
Publicado: (2020)

Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch
por: Yang, Cheng-Wei, et al.
Publicado: (2022)

Rotaviral and Coronaviral Diarrhea
por: Torres-Medina, Alfonso, et al.
Publicado: (1985)

Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine
por: Wang, Ying, et al.
Publicado: (2012)

DCB-3503, a Tylophorine Analog, Inhibits Protein Synthesis through a Novel Mechanism
por: Wang, Ying, et al.
Publicado: (2010)

Regulation of Coronaviral Poly(A) Tail Length during Infection
por: Wu, Hung-Yi, et al.
Publicado: (2013)

Glycan Masking of Hemagglutinin for Adenovirus Vector and Recombinant Protein Immunizations Elicits Broadly Neutralizing Antibodies against H5N1 Avian Influenza Viruses
por: Lin, Shih-Chang, et al.
Publicado: (2014)

Ferret Systemic Coronaviral Disease (FSCD)
Publicado: (2013)

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication
por: Wang, Ying, et al.
Publicado: (2017)

Host proteases as determinants of coronaviral neurotropism and virulence
por: Vavougios, George D.
Publicado: (2020)

Lithium and coronaviral infections. A scoping review.
por: Nowak, Jan K., et al.
Publicado: (2020)

Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Hamilton, M.C.K., et al.
Publicado: (2020)

Neuroimmune multi-hit perspective of coronaviral infection
por: Hayley, Shawn, et al.
Publicado: (2021)

Coronaviral RNA-methyltransferases: function, structure and inhibition
por: Nencka, Radim, et al.
Publicado: (2022)

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents
por: Omran, Ziad, et al.
Publicado: (2021)

Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges
por: Di Sotto, Antonella, et al.
Publicado: (2023)

Modulation of lysosomal function as a therapeutic approach for coronaviral infections
por: Liu, Yuan, et al.
Publicado: (2021)

Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models
por: Yang, Cheng-Yu, et al.
Publicado: (2017)

COVID-19 and coronaviral hepatitis: evidence of collateral damage
por: Parvez, Mohammad K
Publicado: (2020)

Re: Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Morozov, S., et al.
Publicado: (2020)

Feline Infectious Peritonitis: An Immune-Mediated Coronaviral Vasculitis
por: August, John R.
Publicado: (1984)

Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents
por: Godinho, Patrícia I. C., et al.
Publicado: (2021)

Discovery and Nanosized Preparations of (S,R)-Tylophorine Malate as Novel anti-SARS-CoV-2 Agents
por: Wang, Ziwen, et al.
Publicado: (2021)

Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.
por: Chang, Shanshan, et al.
Publicado: (2023)

Allyl Isothiocyanate Suppresses the Proliferation in Oral Squamous Cell Carcinoma via Mediating the KDM8/CCNA1 Axis
por: Hsieh, Cheng-Chih, et al.
Publicado: (2023)

Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor
por: Hu, Xiaohui, et al.
Publicado: (2022)

Anti‐oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient‐derived tumor xenograft model
por: Yang, Cheng‐Yu, et al.
Publicado: (2018)

Membrane and Phospholipid Binding by Murine Coronaviral Nucleocapsid N Protein
por: Anderson, Robert, et al.
Publicado: (1993)

Comparative effectiveness of ultrasound and paraffin therapy in patients with carpal tunnel syndrome: a randomized trial
por: Chang, Yi-Wei, et al.
Publicado: (2014)

Coronaviral Main Protease Induces LPCAT3 Cleavage and Endoplasmic Reticulum (ER) Stress
por: Wang, Jia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fq87aeo7vh71c9ln43j5o2ep51