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FTY720 Prevents Spatial Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via a SIRT3-Independent Pathway

Vascular dementia (VD) and Alzheimer's disease (AD) are the most prevalent types of late-life dementia. Chronic cerebral hypoperfusion (CCH) contributes to both AD and VD. Recently, accumulating evidence has indicated that fingolimod (FTY720) is neuroprotective in acute cerebral ischemic stroke...

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Detalles Bibliográficos
Autores principales: Zhang, Miao, Hu, Yuan, Zhang, Jiahui, Zhang, Junjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845736/
https://www.ncbi.nlm.nih.gov/pubmed/33519419
http://dx.doi.org/10.3389/fnagi.2020.593364