Large pH oscillations promote host defense against human airways infection

The airway mucosal microenvironment is crucial for host defense against inhaled pathogens but remains poorly understood. We report here that the airway surface normally undergoes surprisingly large excursions in pH during breathing that can reach pH 9.0 during inhalation, making it the most alkaline...

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Detalles Bibliográficos
Autores principales: Kim, Dusik, Liao, Jie, Scales, Nathan B., Martini, Carolina, Luan, Xiaojie, Abu-Arish, Asmahan, Robert, Renaud, Luo, Yishan, McKay, Geoffrey A., Nguyen, Dao, Tewfik, Marc A., Poirier, Charles D., Matouk, Elias, Ianowski, Juan P., Frenkiel, Saul, Hanrahan, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845918/
https://www.ncbi.nlm.nih.gov/pubmed/33533914
http://dx.doi.org/10.1084/jem.20201831

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