Persistent cellular immunity to SARS-CoV-2 infection

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SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 in...

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Autores principales: Breton, Gaëlle, Mendoza, Pilar, Hägglöf, Thomas, Oliveira, Thiago Y., Schaefer-Babajew, Dennis, Gaebler, Christian, Turroja, Martina, Hurley, Arlene, Caskey, Marina, Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845919/
https://www.ncbi.nlm.nih.gov/pubmed/33533915
http://dx.doi.org/10.1084/jem.20202515
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author Breton, Gaëlle
Mendoza, Pilar
Hägglöf, Thomas
Oliveira, Thiago Y.
Schaefer-Babajew, Dennis
Gaebler, Christian
Turroja, Martina
Hurley, Arlene
Caskey, Marina
Nussenzweig, Michel C.
author_facet Breton, Gaëlle
Mendoza, Pilar
Hägglöf, Thomas
Oliveira, Thiago Y.
Schaefer-Babajew, Dennis
Gaebler, Christian
Turroja, Martina
Hurley, Arlene
Caskey, Marina
Nussenzweig, Michel C.
author_sort Breton, Gaëlle
collection PubMed
description SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen–specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4(+) and CD8(+) memory T cells, including expression of activation/exhaustion markers, and cell division.
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spelling pubmed-78459192021-02-01 Persistent cellular immunity to SARS-CoV-2 infection Breton, Gaëlle Mendoza, Pilar Hägglöf, Thomas Oliveira, Thiago Y. Schaefer-Babajew, Dennis Gaebler, Christian Turroja, Martina Hurley, Arlene Caskey, Marina Nussenzweig, Michel C. J Exp Med Article SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen–specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4(+) and CD8(+) memory T cells, including expression of activation/exhaustion markers, and cell division. Rockefeller University Press 2021-01-27 /pmc/articles/PMC7845919/ /pubmed/33533915 http://dx.doi.org/10.1084/jem.20202515 Text en © 2021 Breton et al. https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Breton, Gaëlle
Mendoza, Pilar
Hägglöf, Thomas
Oliveira, Thiago Y.
Schaefer-Babajew, Dennis
Gaebler, Christian
Turroja, Martina
Hurley, Arlene
Caskey, Marina
Nussenzweig, Michel C.
Persistent cellular immunity to SARS-CoV-2 infection
title Persistent cellular immunity to SARS-CoV-2 infection
title_full Persistent cellular immunity to SARS-CoV-2 infection
title_fullStr Persistent cellular immunity to SARS-CoV-2 infection
title_full_unstemmed Persistent cellular immunity to SARS-CoV-2 infection
title_short Persistent cellular immunity to SARS-CoV-2 infection
title_sort persistent cellular immunity to sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845919/
https://www.ncbi.nlm.nih.gov/pubmed/33533915
http://dx.doi.org/10.1084/jem.20202515
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