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Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle
Quantitative measurement of nanoscale surface roughness of articular cartilage tissue is significant to assess the surface topography for early treatment of osteoarthritis, the most common joint disease worldwide. Since it was not established by clinical diagnostic tools, the current studies have be...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845957/ https://www.ncbi.nlm.nih.gov/pubmed/33513197 http://dx.doi.org/10.1371/journal.pone.0246395 |
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author | Youssef, Doaa Hassab-Elnaby, Salah El-Ghandoor, Hatem |
author_facet | Youssef, Doaa Hassab-Elnaby, Salah El-Ghandoor, Hatem |
author_sort | Youssef, Doaa |
collection | PubMed |
description | Quantitative measurement of nanoscale surface roughness of articular cartilage tissue is significant to assess the surface topography for early treatment of osteoarthritis, the most common joint disease worldwide. Since it was not established by clinical diagnostic tools, the current studies have been suggesting the use of alternative diagnostic tools using pre-clinical methods. This study aims to measure the nanoscale surface roughness of articular cartilage tissue utilizing biospeckle which is used as a non-destructive and non-contact optical imaging technique. An experimental setup was implemented to capture biospeckle images from twelve cross-section areas of articular cartilage tissue gathered from bovine knee joints at 632 nm wavelength laser radiation. Then, to analyze the biospeckle image, a second-order statistical-based method was proposed through the combination of 308 highly correlated statistical features extracted from implemented gray-level co-occurrence matrices by employing principal component analysis. The result indicated that the measurement of the nanoscale surface roughness based on the first principal component only is able to provide accurate and precise quantitative measurement of early signs of articular cartilage degeneration up to 2500 nm. |
format | Online Article Text |
id | pubmed-7845957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78459572021-02-04 Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle Youssef, Doaa Hassab-Elnaby, Salah El-Ghandoor, Hatem PLoS One Research Article Quantitative measurement of nanoscale surface roughness of articular cartilage tissue is significant to assess the surface topography for early treatment of osteoarthritis, the most common joint disease worldwide. Since it was not established by clinical diagnostic tools, the current studies have been suggesting the use of alternative diagnostic tools using pre-clinical methods. This study aims to measure the nanoscale surface roughness of articular cartilage tissue utilizing biospeckle which is used as a non-destructive and non-contact optical imaging technique. An experimental setup was implemented to capture biospeckle images from twelve cross-section areas of articular cartilage tissue gathered from bovine knee joints at 632 nm wavelength laser radiation. Then, to analyze the biospeckle image, a second-order statistical-based method was proposed through the combination of 308 highly correlated statistical features extracted from implemented gray-level co-occurrence matrices by employing principal component analysis. The result indicated that the measurement of the nanoscale surface roughness based on the first principal component only is able to provide accurate and precise quantitative measurement of early signs of articular cartilage degeneration up to 2500 nm. Public Library of Science 2021-01-29 /pmc/articles/PMC7845957/ /pubmed/33513197 http://dx.doi.org/10.1371/journal.pone.0246395 Text en © 2021 Youssef et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Youssef, Doaa Hassab-Elnaby, Salah El-Ghandoor, Hatem Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle |
title | Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle |
title_full | Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle |
title_fullStr | Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle |
title_full_unstemmed | Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle |
title_short | Nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle |
title_sort | nanoscale quantitative surface roughness measurement of articular cartilage using second-order statistical-based biospeckle |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845957/ https://www.ncbi.nlm.nih.gov/pubmed/33513197 http://dx.doi.org/10.1371/journal.pone.0246395 |
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