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Genome-wide prediction of topoisomerase IIβ binding by architectural factors and chromatin accessibility

DNA topoisomerase II-β (TOP2B) is fundamental to remove topological problems linked to DNA metabolism and 3D chromatin architecture, but its cut-and-reseal catalytic mechanism can accidentally cause DNA double-strand breaks (DSBs) that can seriously compromise genome integrity. Understanding the fac...

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Detalles Bibliográficos
Autores principales:	Martínez-García, Pedro Manuel, García-Torres, Miguel, Divina, Federico, Terrón-Bautista, José, Delgado-Sainz, Irene, Gómez-Vela, Francisco, Cortés-Ledesma, Felipe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845959/ https://www.ncbi.nlm.nih.gov/pubmed/33465072 http://dx.doi.org/10.1371/journal.pcbi.1007814

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