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Coincident glutamatergic depolarizations enhance GABA(A) receptor-dependent Cl(-) influx in mature and suppress Cl(-) efflux in immature neurons
The impact of GABAergic transmission on neuronal excitability depends on the Cl(-)-gradient across membranes. However, the Cl(-)-fluxes through GABA(A) receptors alter the intracellular Cl(-) concentration ([Cl(-)](i)) and in turn attenuate GABAergic responses, a process termed ionic plasticity. Rec...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845986/ https://www.ncbi.nlm.nih.gov/pubmed/33465082 http://dx.doi.org/10.1371/journal.pcbi.1008573 |