Cargando…

Application of a Framework for Grouping and Mixtures Toxicity Assessment of PFAS: A Closer Examination of Dose-Additivity Approaches

Environmental occurrence and biomonitoring data for per- and polyfluoroalkyl substances (PFAS) demonstrate that humans are exposed to mixtures of PFAS. This article presents a new and systematic analysis of available PFAS toxicity study data using a tiered mixtures risk assessment framework consiste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goodrum, Philip E, Anderson, Janet K, Luz, Anthony L, Ansell, Graham K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Regulatory Science, Risk Assessment, and Decision Making
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846094/ https://www.ncbi.nlm.nih.gov/pubmed/32735321 http://dx.doi.org/10.1093/toxsci/kfaa123

Ejemplares similares

Bioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate
por: Danzeisen, Ruth, et al.
Publicado: (2020)

A mode of action-based probabilistic framework of dose-response assessment for nonmutagenic liver carcinogens: a case study of PCB-126
por: Zhou, Yun, et al.
Publicado: (2023)

Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury
por: Monroe, James J, et al.
Publicado: (2020)

A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products
por: Baltazar, Maria T, et al.
Publicado: (2020)

Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids
por: Mallick, Pankajini, et al.
Publicado: (2020)

Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
por: Matar, Hazem, et al.
Publicado: (2019)

Potential of ToxCast Data in the Safety Assessment of Food Chemicals
por: Punt, Ans, et al.
Publicado: (2020)

A Survey of Systematic Evidence Mapping Practice and the Case for Knowledge Graphs in Environmental Health and Toxicology
por: Wolffe, Taylor A M, et al.
Publicado: (2020)

Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt
por: Lenz, Barbara, et al.
Publicado: (2021)

Reliability of the AR-CALUX(®)In Vitro Method Used to Detect Chemicals with (Anti)Androgen Activity: Results of an International Ring Trial
por: Milcamps, Anne, et al.
Publicado: (2021)

Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species
por: Hardwick, Rhiannon N, et al.
Publicado: (2022)

Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow
por: Middleton, Alistair M, et al.
Publicado: (2022)

Manganese relative oral bioavailability in electric arc furnace steel slag is influenced by high iron content and low bioaccessibility
por: Proctor, Deborah M, et al.
Publicado: (2023)

Managing wildlife populations with uncertainty: cormorants Phalacrocorax carbo
por: Smith, G C, et al.
Publicado: (2008)

Family History Is a Predictor for Appendicitis in Adults in the Emergency Department
por: Drescher, Michael J., et al.
Publicado: (2012)

Carprofen and local anaesthesia in calves undergoing disbudding
por: Wareham, Kathryn, et al.
Publicado: (2015)

Renal diets in cats with chronic kidney disease
por: Dean, Rachel, et al.
Publicado: (2015)

REVIEW: Towards a risk register for natural capital
por: Mace, Georgina M., et al.
Publicado: (2015)

Approach to the Diagnosis and Management of Subarachnoid Hemorrhage
por: Marcolini, Evie, et al.
Publicado: (2019)

Review of the Basics of Cognitive Error in Emergency Medicine: Still No Easy Answers
por: Hartigan, Sarah, et al.
Publicado: (2020)

Human and Aquatic Toxicity Potential of Petroleum Biodegradation Metabolite Mixtures in Groundwater from Fuel Release Sites
por: Patterson, Timothy J., et al.
Publicado: (2020)

The chemical exposure toxicity space (CETS) model: Displaying exposure time, aqueous and organic concentration, activity, and onset of toxicity
por: Mackay, Donald, et al.
Publicado: (2016)

Application of a Screening‐Level Pollinator Risk Assessment Framework to Trisiloxane Polyether Surfactants
por: Collins, Jennifer K., et al.
Publicado: (2022)

Mix‐Tool: An Edge‐of‐Field Approach to Predict Pesticide Mixtures of Concern in Surface Water From Agricultural Crops
por: Finizio, Antonio, et al.
Publicado: (2022)

Estimating the effects of Cry1F Bt‐maize pollen on non‐target Lepidoptera using a mathematical model of exposure
por: Perry, Joe N., et al.
Publicado: (2012)

Construction of a risk assessment model of cardiovascular disease in a rural Chinese hypertensive population based on lasso‐Cox analysis
por: Ouyang, Nanxiang, et al.
Publicado: (2021)

Can Chemical Toxicity in Saltwater Be Predicted from Toxicity in Freshwater? A Comprehensive Evaluation Using Species Sensitivity Distributions
por: Yanagihara, Miina, et al.
Publicado: (2022)

Aluminium Ammonium Sulfate and Aluminium Potassium Sulfate (Food Additives)
Publicado: (2019)

Key Opportunities to Replace, Reduce, and Refine Regulatory Fish Acute Toxicity Tests
por: Burden, Natalie, et al.
Publicado: (2020)

A Pulsed‐Dose Study Evaluating Chronic Toxicity of Chlorothalonil to Fish: A Case Study for Environmental Risk Assessment
por: Hamer, Mick, et al.
Publicado: (2019)

Comparison of Substance‐Based and Whole‐Effluent Toxicity of Produced Water Discharges from Norwegian Offshore Oil and Gas Installations
por: de Vries, Pepijn, et al.
Publicado: (2022)

A mixture of 13 pesticides, contaminants, and food additives below individual NOAELs produces histopathological and organ weight changes in rats
por: Dinca, Viorica, et al.
Publicado: (2023)

A framework for the use of single-chemical transcriptomics data in predicting the hazards associated with complex mixtures of polycyclic aromatic hydrocarbons
por: Labib, Sarah, et al.
Publicado: (2016)

Sensitivity of ecological soil-screening levels for metals to exposure model parameterization and toxicity reference values
por: Sample, Bradley E, et al.
Publicado: (2014)

Terrestrial Toxicity of Synthetic Gas‐to‐Liquid versus Crude Oil–Derived Drilling Fluids in Soil
por: Arneson Westbrook, Lisa, et al.
Publicado: (2020)

Modeling Time‐Dependent Aquatic Toxicity of Hydrocarbons: Role of Organism Weight, Temperature, and Substance Hydrophobicity
por: Redman, Aaron D., et al.
Publicado: (2022)

Screening‐Level Estimates of Environmental Release Rates, Predicted Exposures, and Toxic Pressures of Currently Used Chemicals
por: van de Meent, Dik, et al.
Publicado: (2020)

A Comparison of Short‐Term and Continuous Exposures in Toxicity Tests of Produced Waters, Condensate, and Crude Oil to Marine Invertebrates and Fish
por: Gissi, Francesca, et al.
Publicado: (2021)

Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017)
Publicado: (2018)

Novel pricing strategies for revenue maximization and demand learning using an exploration–exploitation framework
por: Elreedy, Dina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2qojevnfffg6eo763818n88r37