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S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity

The Schistosoma mansoni SmKI-1 protein is composed of two domains: a Kunitz-type serine protease inhibitor motif (KD) and a C-terminus domain with no similarity outside the genera. Our previous work has demonstrated that KD plays an essential role in neutrophil elastase (NE) binding blockage, in neu...

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Detalles Bibliográficos
Autores principales:	Mambelli, Fábio, Santos, Bruno P. O., Morais, Suellen B., Gimenez, Enrico G. T., Astoni, Duana C. dos S., Braga, Amanda D., Ferreira, Rafaela S., Amaral, Flávio A., de Magalhães, Mariana T. Q., C. Oliveira, Sergio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846107/ https://www.ncbi.nlm.nih.gov/pubmed/33465126 http://dx.doi.org/10.1371/journal.pntd.0009007

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