Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed...

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Autores principales: Marais, Ben J, Cheong, Elaine, Fernando, Shelanah, Daniel, Santhosh, Watts, Matthew R, Berglund, Lucinda J, Barry, Simone E, Kotsiou, George, Headley, Alex P, Stapledon, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846119/
https://www.ncbi.nlm.nih.gov/pubmed/33542942
http://dx.doi.org/10.1093/ofid/ofaa604
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author Marais, Ben J
Cheong, Elaine
Fernando, Shelanah
Daniel, Santhosh
Watts, Matthew R
Berglund, Lucinda J
Barry, Simone E
Kotsiou, George
Headley, Alex P
Stapledon, Richard A
author_facet Marais, Ben J
Cheong, Elaine
Fernando, Shelanah
Daniel, Santhosh
Watts, Matthew R
Berglund, Lucinda J
Barry, Simone E
Kotsiou, George
Headley, Alex P
Stapledon, Richard A
author_sort Marais, Ben J
collection PubMed
description We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.
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spelling pubmed-78461192021-02-03 Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions Marais, Ben J Cheong, Elaine Fernando, Shelanah Daniel, Santhosh Watts, Matthew R Berglund, Lucinda J Barry, Simone E Kotsiou, George Headley, Alex P Stapledon, Richard A Open Forum Infect Dis Brief Report We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes. Oxford University Press 2020-12-28 /pmc/articles/PMC7846119/ /pubmed/33542942 http://dx.doi.org/10.1093/ofid/ofaa604 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Marais, Ben J
Cheong, Elaine
Fernando, Shelanah
Daniel, Santhosh
Watts, Matthew R
Berglund, Lucinda J
Barry, Simone E
Kotsiou, George
Headley, Alex P
Stapledon, Richard A
Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions
title Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions
title_full Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions
title_fullStr Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions
title_full_unstemmed Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions
title_short Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions
title_sort use of infliximab to treat paradoxical tuberculous meningitis reactions
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846119/
https://www.ncbi.nlm.nih.gov/pubmed/33542942
http://dx.doi.org/10.1093/ofid/ofaa604
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