An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect

Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we present a...

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Autores principales: Mohammad, Lava, Doya, Leen, Omran, Razan, Ibrahim, Alexander, Alshehabi, Zuheir, Ibrahim, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846128/
https://www.ncbi.nlm.nih.gov/pubmed/33542828
http://dx.doi.org/10.1093/omcr/omaa126
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author Mohammad, Lava
Doya, Leen
Omran, Razan
Ibrahim, Alexander
Alshehabi, Zuheir
Ibrahim, Ali
author_facet Mohammad, Lava
Doya, Leen
Omran, Razan
Ibrahim, Alexander
Alshehabi, Zuheir
Ibrahim, Ali
author_sort Mohammad, Lava
collection PubMed
description Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we present a case of a 5-year-old girl with intestinal Tuberculosis, who developed hemiclonic seizure as a side effect of INH therapeutic dose after 2 weeks of tuberculosis therapy.
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spelling pubmed-78461282021-02-03 An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect Mohammad, Lava Doya, Leen Omran, Razan Ibrahim, Alexander Alshehabi, Zuheir Ibrahim, Ali Oxf Med Case Reports Case Report Isoniazid (INH) is highly bactericidal against replicating tubercule bacilli and is involved in all antituberculous chemotherapeutic regimens. Several neurological adverse effects, following both therapeutic and overdose use of INH, have been reported in adults in the literature. Here, we present a case of a 5-year-old girl with intestinal Tuberculosis, who developed hemiclonic seizure as a side effect of INH therapeutic dose after 2 weeks of tuberculosis therapy. Oxford University Press 2021-01-23 /pmc/articles/PMC7846128/ /pubmed/33542828 http://dx.doi.org/10.1093/omcr/omaa126 Text en © The Author(s) 2021. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Mohammad, Lava
Doya, Leen
Omran, Razan
Ibrahim, Alexander
Alshehabi, Zuheir
Ibrahim, Ali
An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
title An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
title_full An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
title_fullStr An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
title_full_unstemmed An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
title_short An unusual case of seizures in a 5-year-old Syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
title_sort unusual case of seizures in a 5-year-old syrian female with abdominal tuberculosis: an isoniazid therapeutic dose side effect
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846128/
https://www.ncbi.nlm.nih.gov/pubmed/33542828
http://dx.doi.org/10.1093/omcr/omaa126
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