Cargando…

Optimal control of a fractional order model for the COVID – 19 pandemic

In this paper a fractional optimal control problem was formulated for the outbreak of COVID-19 using a mathematical model with fractional order derivative in the Caputo sense. The state and co-state equations were given and the best strategy to significantly reduce the spread of COVID-19 infections...

Descripción completa

Detalles Bibliográficos
Autores principales: Baba, Bashir Abdullahi, Bilgehan, Bulent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846236/
https://www.ncbi.nlm.nih.gov/pubmed/33551581
http://dx.doi.org/10.1016/j.chaos.2021.110678
_version_ 1783644699322482688
author Baba, Bashir Abdullahi
Bilgehan, Bulent
author_facet Baba, Bashir Abdullahi
Bilgehan, Bulent
author_sort Baba, Bashir Abdullahi
collection PubMed
description In this paper a fractional optimal control problem was formulated for the outbreak of COVID-19 using a mathematical model with fractional order derivative in the Caputo sense. The state and co-state equations were given and the best strategy to significantly reduce the spread of COVID-19 infections was found by introducing two time-dependent control measures, [Formula: see text] (which represents the awareness campaign, lockdown, and all other measures that reduce the possibility of contacting the disease in susceptible human population) and [Formula: see text] (which represents quarantine, monitoring and treatment of infected humans). Numerical simulations were carried out using RK-4 to show the significance of the control functions. The exposed population in susceptible population is reduced by the factor ([Formula: see text]) due to the awareness and all other measures taken. Likewise, the infected population is reduced by a factor of ([Formula: see text]) due to the monitoring and treatment by health professionals.
format Online
Article
Text
id pubmed-7846236
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-78462362021-02-01 Optimal control of a fractional order model for the COVID – 19 pandemic Baba, Bashir Abdullahi Bilgehan, Bulent Chaos Solitons Fractals Article In this paper a fractional optimal control problem was formulated for the outbreak of COVID-19 using a mathematical model with fractional order derivative in the Caputo sense. The state and co-state equations were given and the best strategy to significantly reduce the spread of COVID-19 infections was found by introducing two time-dependent control measures, [Formula: see text] (which represents the awareness campaign, lockdown, and all other measures that reduce the possibility of contacting the disease in susceptible human population) and [Formula: see text] (which represents quarantine, monitoring and treatment of infected humans). Numerical simulations were carried out using RK-4 to show the significance of the control functions. The exposed population in susceptible population is reduced by the factor ([Formula: see text]) due to the awareness and all other measures taken. Likewise, the infected population is reduced by a factor of ([Formula: see text]) due to the monitoring and treatment by health professionals. Elsevier Ltd. 2021-03 2021-01-29 /pmc/articles/PMC7846236/ /pubmed/33551581 http://dx.doi.org/10.1016/j.chaos.2021.110678 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Baba, Bashir Abdullahi
Bilgehan, Bulent
Optimal control of a fractional order model for the COVID – 19 pandemic
title Optimal control of a fractional order model for the COVID – 19 pandemic
title_full Optimal control of a fractional order model for the COVID – 19 pandemic
title_fullStr Optimal control of a fractional order model for the COVID – 19 pandemic
title_full_unstemmed Optimal control of a fractional order model for the COVID – 19 pandemic
title_short Optimal control of a fractional order model for the COVID – 19 pandemic
title_sort optimal control of a fractional order model for the covid – 19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846236/
https://www.ncbi.nlm.nih.gov/pubmed/33551581
http://dx.doi.org/10.1016/j.chaos.2021.110678
work_keys_str_mv AT bababashirabdullahi optimalcontrolofafractionalordermodelforthecovid19pandemic
AT bilgehanbulent optimalcontrolofafractionalordermodelforthecovid19pandemic