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Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)

Recent publications on the probable role of heparin-binding protein (HBP) as a biomarker in sepsis prompted us to investigate its diagnostic and prognostic performance in severe COVID-19. HBP and IL-6 were measured by immunoassays at admission and on day 7 in 178 patients with pneumonia by SARS-CoV-...

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Autores principales: Saridaki, Maria, Metallidis, Simeon, Grigoropoulou, Sotiria, Vrentzos, Emmanouil, Lada, Malvina, Argyraki, Katerina, Tsachouridou, Olga, Georgiadou, Anna, Vasishta, Anil, Giamarellos-Bourboulis, Evangelos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846268/
https://www.ncbi.nlm.nih.gov/pubmed/33515095
http://dx.doi.org/10.1007/s10096-020-04145-7
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author Saridaki, Maria
Metallidis, Simeon
Grigoropoulou, Sotiria
Vrentzos, Emmanouil
Lada, Malvina
Argyraki, Katerina
Tsachouridou, Olga
Georgiadou, Anna
Vasishta, Anil
Giamarellos-Bourboulis, Evangelos J.
author_facet Saridaki, Maria
Metallidis, Simeon
Grigoropoulou, Sotiria
Vrentzos, Emmanouil
Lada, Malvina
Argyraki, Katerina
Tsachouridou, Olga
Georgiadou, Anna
Vasishta, Anil
Giamarellos-Bourboulis, Evangelos J.
author_sort Saridaki, Maria
collection PubMed
description Recent publications on the probable role of heparin-binding protein (HBP) as a biomarker in sepsis prompted us to investigate its diagnostic and prognostic performance in severe COVID-19. HBP and IL-6 were measured by immunoassays at admission and on day 7 in 178 patients with pneumonia by SARS-CoV-2. Patients were classified into non-sepsis and sepsis as per the Sepsis-3 definitions and were followed up for the development of severe respiratory failure (SRF) and for outcome. Results were confirmed by multivariate analyses. HBP was significantly higher in patients classified as having sepsis and was negatively associated with the oxygenation ratio and positively associated with creatinine and lactate. Logistic regression analysis evidenced admission HBP more than 18 ng/ml and IL-6 more than 30 pg/ml as independent risk factors for the development of SRP. Their integration prognosticated SRF with respective sensitivity, specificity, positive predictive value, and negative predictive 59.1%, 96.3%, 83.9%, and 87.8%. Cox regression analysis evidenced admission HBP more than 35 ng/ml and IL-6 more than 30 pg/ml as independent risk factors for 28-day mortality. Their integration prognosticated 28-day mortality with respective sensitivity, specificity, positive predictive value, and negative predictive value 69.2%, 92.7%, 42.9%, and 97.5%. HBP remained unchanged over-time course. A prediction score of the disposition of patients with COVID-19 is proposed taking into consideration admission levels of IL-6 and HBP. Using different cut-offs, the score may predict the likelihood for SRF and for 28-day outcome. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-020-04145-7.
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spelling pubmed-78462682021-02-01 Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19) Saridaki, Maria Metallidis, Simeon Grigoropoulou, Sotiria Vrentzos, Emmanouil Lada, Malvina Argyraki, Katerina Tsachouridou, Olga Georgiadou, Anna Vasishta, Anil Giamarellos-Bourboulis, Evangelos J. Eur J Clin Microbiol Infect Dis Original Article Recent publications on the probable role of heparin-binding protein (HBP) as a biomarker in sepsis prompted us to investigate its diagnostic and prognostic performance in severe COVID-19. HBP and IL-6 were measured by immunoassays at admission and on day 7 in 178 patients with pneumonia by SARS-CoV-2. Patients were classified into non-sepsis and sepsis as per the Sepsis-3 definitions and were followed up for the development of severe respiratory failure (SRF) and for outcome. Results were confirmed by multivariate analyses. HBP was significantly higher in patients classified as having sepsis and was negatively associated with the oxygenation ratio and positively associated with creatinine and lactate. Logistic regression analysis evidenced admission HBP more than 18 ng/ml and IL-6 more than 30 pg/ml as independent risk factors for the development of SRP. Their integration prognosticated SRF with respective sensitivity, specificity, positive predictive value, and negative predictive 59.1%, 96.3%, 83.9%, and 87.8%. Cox regression analysis evidenced admission HBP more than 35 ng/ml and IL-6 more than 30 pg/ml as independent risk factors for 28-day mortality. Their integration prognosticated 28-day mortality with respective sensitivity, specificity, positive predictive value, and negative predictive value 69.2%, 92.7%, 42.9%, and 97.5%. HBP remained unchanged over-time course. A prediction score of the disposition of patients with COVID-19 is proposed taking into consideration admission levels of IL-6 and HBP. Using different cut-offs, the score may predict the likelihood for SRF and for 28-day outcome. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-020-04145-7. Springer Berlin Heidelberg 2021-01-29 2021 /pmc/articles/PMC7846268/ /pubmed/33515095 http://dx.doi.org/10.1007/s10096-020-04145-7 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Saridaki, Maria
Metallidis, Simeon
Grigoropoulou, Sotiria
Vrentzos, Emmanouil
Lada, Malvina
Argyraki, Katerina
Tsachouridou, Olga
Georgiadou, Anna
Vasishta, Anil
Giamarellos-Bourboulis, Evangelos J.
Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)
title Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)
title_full Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)
title_fullStr Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)
title_full_unstemmed Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)
title_short Integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by SARS-CoV-2 (COVID-19)
title_sort integration of heparin-binding protein and interleukin-6 in the early prediction of respiratory failure and mortality in pneumonia by sars-cov-2 (covid-19)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846268/
https://www.ncbi.nlm.nih.gov/pubmed/33515095
http://dx.doi.org/10.1007/s10096-020-04145-7
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