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The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subsequent studies did not observe these lesions. The c...

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Detalles Bibliográficos
Autores principales:	Polaski, Jacob T, Udy, Dylan B, Escobar-Hoyos, Luisa F, Askan, Gokce, Leach, Steven D, Ventura, Andrea, Kannan, Ram, Bradley, Robert K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846273/ https://www.ncbi.nlm.nih.gov/pubmed/33404013 http://dx.doi.org/10.7554/eLife.62209

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