Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

BACKGROUND: Kinase oxidation is a critical signaling mechanism through which changes in the intracellular redox state alter cardiac function. In the myocardium, PKARIα (type-1 protein kinase A) can be reversibly oxidized, forming interprotein disulfide bonds in the holoenzyme complex. However, the e...

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Detalles Bibliográficos
Autores principales: Simon, Jillian N., Vrellaku, Besarte, Monterisi, Stefania, Chu, Sandy M., Rawlings, Nadiia, Lomas, Oliver, Marchal, Gerard A., Waithe, Dominic, Syeda, Fahima, Gajendragadkar, Parag R., Jayaram, Raja, Sayeed, Rana, Channon, Keith M., Fabritz, Larissa, Swietach, Pawel, Zaccolo, Manuela, Eaton, Philip, Casadei, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846288/
https://www.ncbi.nlm.nih.gov/pubmed/33185461
http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046761

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