Cargando…

Dihydroartemisinin attenuates osteoarthritis by inhibiting abnormal bone remodeling and angiogenesis in subchondral bone

The present study aimed to investigate whether dihydroartemisinin (DHA) alleviates osteoarthritis (OA) in a mouse model of OA. Ten-week-old female C57BL/6j mice were used to establish OA models by anterior cruciate ligament transection (ACLT) and ovariectomized (OVX). DHA was then used to treat the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Long, Zhao, Xin, Liu, Yibin, Wu, Jiang, Yang, Xiaochun, Jin, Qunhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846423/ https://www.ncbi.nlm.nih.gov/pubmed/33448319 http://dx.doi.org/10.3892/ijmm.2021.4855

Ejemplares similares

Osteoclasts secrete leukemia inhibitory factor to promote abnormal bone remodeling of subchondral bone in osteoarthritis
por: Zhao, Xin, et al.
Publicado: (2022)

Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling
por: Yan, Jiangbo, et al.
Publicado: (2023)

Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway
por: Guo, Haohui, et al.
Publicado: (2021)

Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone
por: Yajun, Wang, et al.
Publicado: (2021)

Sclerostin expression in the subchondral bone of patients with knee osteoarthritis
por: Wu, Long, et al.
Publicado: (2016)

Subchondral bone remodelling and osteoarthritis
por: Román-Blas, Jorge A, et al.
Publicado: (2012)

Subchondral bone remodelling in osteoarthritis
por: Donell, Simon
Publicado: (2019)

Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone
por: Ji, Baochao, et al.
Publicado: (2018)

Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption
por: Ding, Dong, et al.
Publicado: (2022)

Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis
por: Yan, Jiangbo, et al.
Publicado: (2022)

Halofuginone Attenuates Osteoarthritis by Rescuing Bone Remodeling in Subchondral Bone Through Oral Gavage
por: Mu, Wenbo, et al.
Publicado: (2018)

Dickkopf-3 and β-catenin play opposite roles in the Wnt/β-catenin pathway during the abnormal subchondral bone formation of human knee osteoarthritis
por: Liang, Xuegang, et al.
Publicado: (2022)

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis
por: Yang, Xiaochun, et al.
Publicado: (2022)

Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice
por: Sun, Qi, et al.
Publicado: (2021)

Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis
por: Sun, Qi, et al.
Publicado: (2022)

Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF-κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis
por: Ding, Dong, et al.
Publicado: (2022)

Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis
por: Zhu, Xiaobo, et al.
Publicado: (2021)

Inhibition of SDF-1/CXCR4 Axis to Alleviate Abnormal Bone Formation and Angiogenesis Could Improve the Subchondral Bone Microenvironment in Osteoarthritis
por: Qin, Hanjun, et al.
Publicado: (2021)

Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation
por: Li, Bin, et al.
Publicado: (2021)

Antioxidant PDA-PEG nanoparticles alleviate early osteoarthritis by inhibiting osteoclastogenesis and angiogenesis in subchondral bone
por: Wu, Zhikai, et al.
Publicado: (2022)

Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis
por: Zhen, Gehua, et al.
Publicado: (2013)

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone
por: Cui, Zhuang, et al.
Publicado: (2016)

Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
por: Cui, Zhuang, et al.
Publicado: (2022)

Subchondral bone architecture and quality in osteoarthritis
por: Aspden, RM
Publicado: (2004)

Targeting subchondral bone in osteoporotic osteoarthritis
por: Roman-Blas, Jorge A, et al.
Publicado: (2014)

The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis
por: Stewart, Holly L., et al.
Publicado: (2018)

Subchondral bone histology and grading in osteoarthritis
por: Aho, Olli-Matti, et al.
Publicado: (2017)

Subchondral bone microenvironment in osteoarthritis and pain
por: Hu, Yan, et al.
Publicado: (2021)

Low frequency pulsed electromagnetic fields exposure alleviate the abnormal subchondral bone remodeling at the early stage of temporomandibular joint osteoarthritis
por: Ma, Yuanjun, et al.
Publicado: (2022)

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
por: Bellido, Miriam, et al.
Publicado: (2010)

Calcium-phosphate complex increased during subchondral bone remodeling affects earlystage osteoarthritis
por: Jung, Youn-Kwan, et al.
Publicado: (2018)

Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis
por: Xu, Xiao, et al.
Publicado: (2019)

Correction: Low frequency pulsed electromagnetic fields exposure alleviate the abnormal subchondral bone remodeling at the early stage of temporomandibular joint osteoarthritis
por: Ma, Yuanjun, et al.
Publicado: (2023)

Microstructural analysis of subchondral bone in knee osteoarthritis
por: Holzer, L.A., et al.
Publicado: (2020)

Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis
por: Ball, Hope C., et al.
Publicado: (2022)

Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis
por: Dong, Yonghui, et al.
Publicado: (2016)

Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis
por: Tu, Manli, et al.
Publicado: (2019)

Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
por: Zhuang, Chenyang, et al.
Publicado: (2021)

Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling
por: Zhang, Lixia, et al.
Publicado: (2021)

Defactinib attenuates osteoarthritis by inhibiting positive feedback loop between H-type vessels and MSCs in subchondral bone
por: Hu, Yanjun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pgraujed9hl20schaobjbjqdgp