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Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis
Posterior reversible encephalopathy syndrome is a rare syndrome characterized by brain edema and neurological symptoms, often resulting from several drugs. Treatment is based on discontinuation, and diagnosis is thus essential. Only 13 cases of posterior reversible encephalopathy syndrome have been...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846476/ https://www.ncbi.nlm.nih.gov/pubmed/33532511 http://dx.doi.org/10.14309/crj.0000000000000521 |
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author | Vernia, Filippo Di Ruscio, Mirko Massella, Arianna Variola, Angela Montanari, Renzo Bocus, Paolo |
author_facet | Vernia, Filippo Di Ruscio, Mirko Massella, Arianna Variola, Angela Montanari, Renzo Bocus, Paolo |
author_sort | Vernia, Filippo |
collection | PubMed |
description | Posterior reversible encephalopathy syndrome is a rare syndrome characterized by brain edema and neurological symptoms, often resulting from several drugs. Treatment is based on discontinuation, and diagnosis is thus essential. Only 13 cases of posterior reversible encephalopathy syndrome have been reported in inflammatory bowel diseases, and we present the first after azathioprine in adults. A 56-year-old patient with active ulcerative colitis was found unconscious 5 days after the institution of azathioprine. Right-sided hemiplegia was found after the patient regained consciousness. Magnetic resonance imaging showed altered signal associated with diffusion restriction in the occipital lobe and cerebral vasogenic edema. Complete regression of neurological signs occurred after azathioprine discontinuation. |
format | Online Article Text |
id | pubmed-7846476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-78464762021-02-01 Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis Vernia, Filippo Di Ruscio, Mirko Massella, Arianna Variola, Angela Montanari, Renzo Bocus, Paolo ACG Case Rep J Case Report Posterior reversible encephalopathy syndrome is a rare syndrome characterized by brain edema and neurological symptoms, often resulting from several drugs. Treatment is based on discontinuation, and diagnosis is thus essential. Only 13 cases of posterior reversible encephalopathy syndrome have been reported in inflammatory bowel diseases, and we present the first after azathioprine in adults. A 56-year-old patient with active ulcerative colitis was found unconscious 5 days after the institution of azathioprine. Right-sided hemiplegia was found after the patient regained consciousness. Magnetic resonance imaging showed altered signal associated with diffusion restriction in the occipital lobe and cerebral vasogenic edema. Complete regression of neurological signs occurred after azathioprine discontinuation. Wolters Kluwer 2021-01-29 /pmc/articles/PMC7846476/ /pubmed/33532511 http://dx.doi.org/10.14309/crj.0000000000000521 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Case Report Vernia, Filippo Di Ruscio, Mirko Massella, Arianna Variola, Angela Montanari, Renzo Bocus, Paolo Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis |
title | Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis |
title_full | Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis |
title_fullStr | Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis |
title_full_unstemmed | Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis |
title_short | Posterior Reversible Encephalopathy Syndrome After Azathioprine Administration in Severe Ulcerative Colitis |
title_sort | posterior reversible encephalopathy syndrome after azathioprine administration in severe ulcerative colitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846476/ https://www.ncbi.nlm.nih.gov/pubmed/33532511 http://dx.doi.org/10.14309/crj.0000000000000521 |
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