Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

Polycomb repressive complex 2 (PRC2) is a histone methyltransferase critical for maintaining gene silencing during eukaryotic development. In mammals, PRC2 activity is regulated in part by the selective incorporation of one of two paralogs of the catalytic subunit, EZH1 or EZH2. Each of these enzyme...

Descripción completa

Detalles Bibliográficos
Autores principales: Grau, Daniel, Zhang, Yixiao, Lee, Chul-Hwan, Valencia-Sánchez, Marco, Zhang, Jenny, Wang, Miao, Holder, Marlene, Svetlov, Vladimir, Tan, Dongyan, Nudler, Evgeny, Reinberg, Danny, Walz, Thomas, Armache, Karim-Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846606/
https://www.ncbi.nlm.nih.gov/pubmed/33514705
http://dx.doi.org/10.1038/s41467-020-20775-z

Ejemplares similares

Ejemplares similares