Posttranslational chemical installation of azoles into translated peptides

Azoles are five-membered heterocycles often found in the backbones of peptidic natural products and synthetic peptidomimetics. Here, we report a method of ribosomal synthesis of azole-containing peptides involving specific ribosomal incorporation of a bromovinylglycine derivative into the nascent pe...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Haruka, Kuroda, Tomohiro, Kimura, Hiroyuki, Goto, Yuki, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846737/
https://www.ncbi.nlm.nih.gov/pubmed/33514734
http://dx.doi.org/10.1038/s41467-021-20992-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846737/
https://www.ncbi.nlm.nih.gov/pubmed/33514734
http://dx.doi.org/10.1038/s41467-021-20992-0

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