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Posttranslational chemical installation of azoles into translated peptides
Azoles are five-membered heterocycles often found in the backbones of peptidic natural products and synthetic peptidomimetics. Here, we report a method of ribosomal synthesis of azole-containing peptides involving specific ribosomal incorporation of a bromovinylglycine derivative into the nascent pe...
Autores principales: | Tsutsumi, Haruka, Kuroda, Tomohiro, Kimura, Hiroyuki, Goto, Yuki, Suga, Hiroaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846737/ https://www.ncbi.nlm.nih.gov/pubmed/33514734 http://dx.doi.org/10.1038/s41467-021-20992-0 |
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