Perspectives on skeletal muscle stem cells

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and G...

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Autores principales: Relaix, F., Bencze, M., Borok, M. J., Der Vartanian, A., Gattazzo, F., Mademtzoglou, D., Perez-Diaz, S., Prola, A., Reyes-Fernandez, P. C., Rotini, A., Taglietti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846784/
https://www.ncbi.nlm.nih.gov/pubmed/33514709
http://dx.doi.org/10.1038/s41467-020-20760-6
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author Relaix, F.
Bencze, M.
Borok, M. J.
Der Vartanian, A.
Gattazzo, F.
Mademtzoglou, D.
Perez-Diaz, S.
Prola, A.
Reyes-Fernandez, P. C.
Rotini, A.
Taglietti
author_facet Relaix, F.
Bencze, M.
Borok, M. J.
Der Vartanian, A.
Gattazzo, F.
Mademtzoglou, D.
Perez-Diaz, S.
Prola, A.
Reyes-Fernandez, P. C.
Rotini, A.
Taglietti
author_sort Relaix, F.
collection PubMed
description Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and G(alert) states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine.
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spelling pubmed-78467842021-02-08 Perspectives on skeletal muscle stem cells Relaix, F. Bencze, M. Borok, M. J. Der Vartanian, A. Gattazzo, F. Mademtzoglou, D. Perez-Diaz, S. Prola, A. Reyes-Fernandez, P. C. Rotini, A. Taglietti Nat Commun Review Article Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and G(alert) states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine. Nature Publishing Group UK 2021-01-29 /pmc/articles/PMC7846784/ /pubmed/33514709 http://dx.doi.org/10.1038/s41467-020-20760-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Relaix, F.
Bencze, M.
Borok, M. J.
Der Vartanian, A.
Gattazzo, F.
Mademtzoglou, D.
Perez-Diaz, S.
Prola, A.
Reyes-Fernandez, P. C.
Rotini, A.
Taglietti
Perspectives on skeletal muscle stem cells
title Perspectives on skeletal muscle stem cells
title_full Perspectives on skeletal muscle stem cells
title_fullStr Perspectives on skeletal muscle stem cells
title_full_unstemmed Perspectives on skeletal muscle stem cells
title_short Perspectives on skeletal muscle stem cells
title_sort perspectives on skeletal muscle stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846784/
https://www.ncbi.nlm.nih.gov/pubmed/33514709
http://dx.doi.org/10.1038/s41467-020-20760-6
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