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In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine

Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene or chamazulene, occur in nature as components of many plants and mushrooms, such as Matricaria chamomilla, Artemisia absinthium, Achillea mi...

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Autores principales: Bakun, Paweł, Czarczynska-Goslinska, Beata, Goslinski, Tomasz, Lijewski, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847300/
https://www.ncbi.nlm.nih.gov/pubmed/33551629
http://dx.doi.org/10.1007/s00044-021-02701-0
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author Bakun, Paweł
Czarczynska-Goslinska, Beata
Goslinski, Tomasz
Lijewski, Sebastian
author_facet Bakun, Paweł
Czarczynska-Goslinska, Beata
Goslinski, Tomasz
Lijewski, Sebastian
author_sort Bakun, Paweł
collection PubMed
description Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene or chamazulene, occur in nature as components of many plants and mushrooms, such as Matricaria chamomilla, Artemisia absinthium, Achillea millefolium, and Lactarius indigo. Due to physicochemical properties, azulene and its derivatives have found many potential applications in technology, especially in optoelectronic devices. In medicine, the ingredients of these plants have been widely used for hundreds of years in antiallergic, antibacterial, and anti-inflammatory therapies. Herein, the applications of azulene, its derivatives and their conjugates with biologically active compounds are presented. The potential use of these compounds concerns various areas of medicine, including anti-inflammatory with peptic ulcers, antineoplastic with leukemia, antidiabetes, antiretroviral with HIV-1, antimicrobial, including antimicrobial photodynamic therapy, and antifungal. [Image: see text]
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spelling pubmed-78473002021-02-01 In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine Bakun, Paweł Czarczynska-Goslinska, Beata Goslinski, Tomasz Lijewski, Sebastian Med Chem Res Review Article Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene or chamazulene, occur in nature as components of many plants and mushrooms, such as Matricaria chamomilla, Artemisia absinthium, Achillea millefolium, and Lactarius indigo. Due to physicochemical properties, azulene and its derivatives have found many potential applications in technology, especially in optoelectronic devices. In medicine, the ingredients of these plants have been widely used for hundreds of years in antiallergic, antibacterial, and anti-inflammatory therapies. Herein, the applications of azulene, its derivatives and their conjugates with biologically active compounds are presented. The potential use of these compounds concerns various areas of medicine, including anti-inflammatory with peptic ulcers, antineoplastic with leukemia, antidiabetes, antiretroviral with HIV-1, antimicrobial, including antimicrobial photodynamic therapy, and antifungal. [Image: see text] Springer US 2021-01-30 2021 /pmc/articles/PMC7847300/ /pubmed/33551629 http://dx.doi.org/10.1007/s00044-021-02701-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Bakun, Paweł
Czarczynska-Goslinska, Beata
Goslinski, Tomasz
Lijewski, Sebastian
In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
title In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
title_full In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
title_fullStr In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
title_full_unstemmed In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
title_short In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
title_sort in vitro and in vivo biological activities of azulene derivatives with potential applications in medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847300/
https://www.ncbi.nlm.nih.gov/pubmed/33551629
http://dx.doi.org/10.1007/s00044-021-02701-0
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