Cargando…

Brain functional networks associated with social bonding in monogamous voles

Previous studies have related pair-bonding in Microtus ochrogaster, the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially relevant regions have yet to be described. In this study, we used resting-state magnetic resonance imaging to explore...

Descripción completa

Detalles Bibliográficos
Autores principales: López-Gutiérrez, M Fernanda, Gracia-Tabuenca, Zeus, Ortiz, Juan J, Camacho, Francisco J, Young, Larry J, Paredes, Raúl G, Díaz, Néstor F, Portillo, Wendy, Alcauter, Sarael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847304/
https://www.ncbi.nlm.nih.gov/pubmed/33443015
http://dx.doi.org/10.7554/eLife.55081
_version_ 1783644904959770624
author López-Gutiérrez, M Fernanda
Gracia-Tabuenca, Zeus
Ortiz, Juan J
Camacho, Francisco J
Young, Larry J
Paredes, Raúl G
Díaz, Néstor F
Portillo, Wendy
Alcauter, Sarael
author_facet López-Gutiérrez, M Fernanda
Gracia-Tabuenca, Zeus
Ortiz, Juan J
Camacho, Francisco J
Young, Larry J
Paredes, Raúl G
Díaz, Néstor F
Portillo, Wendy
Alcauter, Sarael
author_sort López-Gutiérrez, M Fernanda
collection PubMed
description Previous studies have related pair-bonding in Microtus ochrogaster, the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially relevant regions have yet to be described. In this study, we used resting-state magnetic resonance imaging to explore bonding behaviors and functional connectivity of brain regions previously associated with pair-bonding. Thirty-two male and female prairie voles were scanned at baseline, 24 hr, and 2 weeks after the onset of cohabitation. By using network-based statistics, we identified that the functional connectivity of a corticostriatal network predicted the onset of affiliative behavior, while another predicted the amount of social interaction during a partner preference test. Furthermore, a network with significant changes in time was revealed, also showing associations with the level of partner preference. Overall, our findings revealed the association between network-level functional connectivity changes and social bonding.
format Online
Article
Text
id pubmed-7847304
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-78473042021-02-01 Brain functional networks associated with social bonding in monogamous voles López-Gutiérrez, M Fernanda Gracia-Tabuenca, Zeus Ortiz, Juan J Camacho, Francisco J Young, Larry J Paredes, Raúl G Díaz, Néstor F Portillo, Wendy Alcauter, Sarael eLife Neuroscience Previous studies have related pair-bonding in Microtus ochrogaster, the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially relevant regions have yet to be described. In this study, we used resting-state magnetic resonance imaging to explore bonding behaviors and functional connectivity of brain regions previously associated with pair-bonding. Thirty-two male and female prairie voles were scanned at baseline, 24 hr, and 2 weeks after the onset of cohabitation. By using network-based statistics, we identified that the functional connectivity of a corticostriatal network predicted the onset of affiliative behavior, while another predicted the amount of social interaction during a partner preference test. Furthermore, a network with significant changes in time was revealed, also showing associations with the level of partner preference. Overall, our findings revealed the association between network-level functional connectivity changes and social bonding. eLife Sciences Publications, Ltd 2021-01-14 /pmc/articles/PMC7847304/ /pubmed/33443015 http://dx.doi.org/10.7554/eLife.55081 Text en © 2021, López-Gutiérrez et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
López-Gutiérrez, M Fernanda
Gracia-Tabuenca, Zeus
Ortiz, Juan J
Camacho, Francisco J
Young, Larry J
Paredes, Raúl G
Díaz, Néstor F
Portillo, Wendy
Alcauter, Sarael
Brain functional networks associated with social bonding in monogamous voles
title Brain functional networks associated with social bonding in monogamous voles
title_full Brain functional networks associated with social bonding in monogamous voles
title_fullStr Brain functional networks associated with social bonding in monogamous voles
title_full_unstemmed Brain functional networks associated with social bonding in monogamous voles
title_short Brain functional networks associated with social bonding in monogamous voles
title_sort brain functional networks associated with social bonding in monogamous voles
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847304/
https://www.ncbi.nlm.nih.gov/pubmed/33443015
http://dx.doi.org/10.7554/eLife.55081
work_keys_str_mv AT lopezgutierrezmfernanda brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT graciatabuencazeus brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT ortizjuanj brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT camachofranciscoj brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT younglarryj brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT paredesraulg brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT diaznestorf brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT portillowendy brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles
AT alcautersarael brainfunctionalnetworksassociatedwithsocialbondinginmonogamousvoles