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Brain functional networks associated with social bonding in monogamous voles
Previous studies have related pair-bonding in Microtus ochrogaster, the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially relevant regions have yet to be described. In this study, we used resting-state magnetic resonance imaging to explore...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847304/ https://www.ncbi.nlm.nih.gov/pubmed/33443015 http://dx.doi.org/10.7554/eLife.55081 |
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author | López-Gutiérrez, M Fernanda Gracia-Tabuenca, Zeus Ortiz, Juan J Camacho, Francisco J Young, Larry J Paredes, Raúl G Díaz, Néstor F Portillo, Wendy Alcauter, Sarael |
author_facet | López-Gutiérrez, M Fernanda Gracia-Tabuenca, Zeus Ortiz, Juan J Camacho, Francisco J Young, Larry J Paredes, Raúl G Díaz, Néstor F Portillo, Wendy Alcauter, Sarael |
author_sort | López-Gutiérrez, M Fernanda |
collection | PubMed |
description | Previous studies have related pair-bonding in Microtus ochrogaster, the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially relevant regions have yet to be described. In this study, we used resting-state magnetic resonance imaging to explore bonding behaviors and functional connectivity of brain regions previously associated with pair-bonding. Thirty-two male and female prairie voles were scanned at baseline, 24 hr, and 2 weeks after the onset of cohabitation. By using network-based statistics, we identified that the functional connectivity of a corticostriatal network predicted the onset of affiliative behavior, while another predicted the amount of social interaction during a partner preference test. Furthermore, a network with significant changes in time was revealed, also showing associations with the level of partner preference. Overall, our findings revealed the association between network-level functional connectivity changes and social bonding. |
format | Online Article Text |
id | pubmed-7847304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78473042021-02-01 Brain functional networks associated with social bonding in monogamous voles López-Gutiérrez, M Fernanda Gracia-Tabuenca, Zeus Ortiz, Juan J Camacho, Francisco J Young, Larry J Paredes, Raúl G Díaz, Néstor F Portillo, Wendy Alcauter, Sarael eLife Neuroscience Previous studies have related pair-bonding in Microtus ochrogaster, the prairie vole, with plastic changes in several brain regions. However, the interactions between these socially relevant regions have yet to be described. In this study, we used resting-state magnetic resonance imaging to explore bonding behaviors and functional connectivity of brain regions previously associated with pair-bonding. Thirty-two male and female prairie voles were scanned at baseline, 24 hr, and 2 weeks after the onset of cohabitation. By using network-based statistics, we identified that the functional connectivity of a corticostriatal network predicted the onset of affiliative behavior, while another predicted the amount of social interaction during a partner preference test. Furthermore, a network with significant changes in time was revealed, also showing associations with the level of partner preference. Overall, our findings revealed the association between network-level functional connectivity changes and social bonding. eLife Sciences Publications, Ltd 2021-01-14 /pmc/articles/PMC7847304/ /pubmed/33443015 http://dx.doi.org/10.7554/eLife.55081 Text en © 2021, López-Gutiérrez et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience López-Gutiérrez, M Fernanda Gracia-Tabuenca, Zeus Ortiz, Juan J Camacho, Francisco J Young, Larry J Paredes, Raúl G Díaz, Néstor F Portillo, Wendy Alcauter, Sarael Brain functional networks associated with social bonding in monogamous voles |
title | Brain functional networks associated with social bonding in monogamous voles |
title_full | Brain functional networks associated with social bonding in monogamous voles |
title_fullStr | Brain functional networks associated with social bonding in monogamous voles |
title_full_unstemmed | Brain functional networks associated with social bonding in monogamous voles |
title_short | Brain functional networks associated with social bonding in monogamous voles |
title_sort | brain functional networks associated with social bonding in monogamous voles |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847304/ https://www.ncbi.nlm.nih.gov/pubmed/33443015 http://dx.doi.org/10.7554/eLife.55081 |
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