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Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals

Myocardial strain is a well-validated parameter for evaluating myocardial contraction. Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a novel method for the quantitative measurements of myocardial strain from routine cine acquisitions. In this study, we investigated the in...

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Autores principales: Li, Hao, Qu, Yangyang, Metze, Patrick, Sommerfeld, Florian, Just, Steffen, Abaei, Alireza, Rasche, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847329/
https://www.ncbi.nlm.nih.gov/pubmed/33553431
http://dx.doi.org/10.1155/2021/8492705
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author Li, Hao
Qu, Yangyang
Metze, Patrick
Sommerfeld, Florian
Just, Steffen
Abaei, Alireza
Rasche, Volker
author_facet Li, Hao
Qu, Yangyang
Metze, Patrick
Sommerfeld, Florian
Just, Steffen
Abaei, Alireza
Rasche, Volker
author_sort Li, Hao
collection PubMed
description Myocardial strain is a well-validated parameter for evaluating myocardial contraction. Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a novel method for the quantitative measurements of myocardial strain from routine cine acquisitions. In this study, we investigated the influence of temporal resolution on tracking accuracy of CMR-FT and the intraobserver, interobserver, and interstudy reproducibilities for biventricular strain analysis in mice from self-gated CMR at 11.7 T. 12 constitutive nexilin knockout (Nexn-KO) mice, heterozygous (Het, N = 6) and wild-type (WT, N = 6), were measured with a well-established self-gating sequence twice within two weeks. CMR-FT measures of biventricular global and segmental strain parameters were derived. Interstudy, intraobserver, and interobserver reproducibilities were investigated. For the assessment of the impact of the temporal resolution for the outcome in CMR-FT, highly oversampled semi-4 chamber and midventricular short-axis data were acquired and reconstructed with 10 to 80 phases per cardiac cycle. A generally reduced biventricular myocardial strain was observed in Nexn-KO Het mice. Excellent intraobserver and interobserver reproducibility was achieved in all global strains (ICC range from 0.76 to 0.99), where global right ventricle circumferential strain (RCS(SAX)) showed an only good interobserver reproducibility (ICC 0.65, 0.11-0.89). For interstudy reproducibility, left ventricle longitudinal strain (LLS(LAX)) was the most reproducible measure of strain (ICC 0.90, 0.71-0.97). The left ventricle radial strain (LRS(SAX)) (ICC 0.50, 0.10-0.83) showed fair reproducibility and RCS(SAX) (ICC 0.36, 0.14-0.74) showed only poor reproducibility. In general, compared with global strains, the segmental strains showed relatively lower reproducibility. A minimal temporal resolution of 20 phases per cardiac cycle appeared sufficient for CMR-FT strain analysis. The analysis of myocardial strain from high-resolution self-gated cine images by CMR-FT provides a highly reproducible method for assessing myocardial contraction in small rodent animals. Especially, global LV longitudinal and circumferential strain revealed excellent reproducibility of intra- and interobserver and interstudy measurements.
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spelling pubmed-78473292021-02-04 Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals Li, Hao Qu, Yangyang Metze, Patrick Sommerfeld, Florian Just, Steffen Abaei, Alireza Rasche, Volker Biomed Res Int Research Article Myocardial strain is a well-validated parameter for evaluating myocardial contraction. Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a novel method for the quantitative measurements of myocardial strain from routine cine acquisitions. In this study, we investigated the influence of temporal resolution on tracking accuracy of CMR-FT and the intraobserver, interobserver, and interstudy reproducibilities for biventricular strain analysis in mice from self-gated CMR at 11.7 T. 12 constitutive nexilin knockout (Nexn-KO) mice, heterozygous (Het, N = 6) and wild-type (WT, N = 6), were measured with a well-established self-gating sequence twice within two weeks. CMR-FT measures of biventricular global and segmental strain parameters were derived. Interstudy, intraobserver, and interobserver reproducibilities were investigated. For the assessment of the impact of the temporal resolution for the outcome in CMR-FT, highly oversampled semi-4 chamber and midventricular short-axis data were acquired and reconstructed with 10 to 80 phases per cardiac cycle. A generally reduced biventricular myocardial strain was observed in Nexn-KO Het mice. Excellent intraobserver and interobserver reproducibility was achieved in all global strains (ICC range from 0.76 to 0.99), where global right ventricle circumferential strain (RCS(SAX)) showed an only good interobserver reproducibility (ICC 0.65, 0.11-0.89). For interstudy reproducibility, left ventricle longitudinal strain (LLS(LAX)) was the most reproducible measure of strain (ICC 0.90, 0.71-0.97). The left ventricle radial strain (LRS(SAX)) (ICC 0.50, 0.10-0.83) showed fair reproducibility and RCS(SAX) (ICC 0.36, 0.14-0.74) showed only poor reproducibility. In general, compared with global strains, the segmental strains showed relatively lower reproducibility. A minimal temporal resolution of 20 phases per cardiac cycle appeared sufficient for CMR-FT strain analysis. The analysis of myocardial strain from high-resolution self-gated cine images by CMR-FT provides a highly reproducible method for assessing myocardial contraction in small rodent animals. Especially, global LV longitudinal and circumferential strain revealed excellent reproducibility of intra- and interobserver and interstudy measurements. Hindawi 2021-01-22 /pmc/articles/PMC7847329/ /pubmed/33553431 http://dx.doi.org/10.1155/2021/8492705 Text en Copyright © 2021 Hao Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Hao
Qu, Yangyang
Metze, Patrick
Sommerfeld, Florian
Just, Steffen
Abaei, Alireza
Rasche, Volker
Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals
title Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals
title_full Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals
title_fullStr Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals
title_full_unstemmed Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals
title_short Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small Animals
title_sort quantification of biventricular myocardial strain using cmr feature tracking: reproducibility in small animals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847329/
https://www.ncbi.nlm.nih.gov/pubmed/33553431
http://dx.doi.org/10.1155/2021/8492705
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