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Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axonal function is a highly energy-demanding process, r...

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Detalles Bibliográficos
Autores principales:	Mehta, Arpan R., Gregory, Jenna M., Dando, Owen, Carter, Roderick N., Burr, Karen, Nanda, Jyoti, Story, David, McDade, Karina, Smith, Colin, Morton, Nicholas M., Mahad, Don J., Hardingham, Giles E., Chandran, Siddharthan, Selvaraj, Bhuvaneish T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847443/ https://www.ncbi.nlm.nih.gov/pubmed/33398403 http://dx.doi.org/10.1007/s00401-020-02252-5

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