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ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria

The ClpP1P2 proteolytic complex is essential in Mycobacterium tuberculosis. Proteolysis by ClpP1P2 requires an associated ATPase, either ClpX or ClpC1. Here, we sought to define the unique contributions of the ClpX ATPase to mycobacterial growth. We formally demonstrated that ClpX is essential for m...

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Detalles Bibliográficos
Autores principales:	Kester, Jemila C., Kandror, Olga, Akopian, Tatos, Chase, Michael R., Zhu, Junhao, Rubin, Eric J., Goldberg, Alfred L., Fortune, Sarah M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847540/ https://www.ncbi.nlm.nih.gov/pubmed/33229461 http://dx.doi.org/10.1128/JB.00608-20

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