Combination gene therapy for HIV using a conditional suicidal gene with CCR5 knockout

BACKGROUND: Gene therapy approaches using hematopoietic stem cells to generate an HIV resistant immune system have been shown to be successful. The deletion of HIV co-receptor CCR5 remains a viable strategy although co-receptor switching to CXCR4 remains a major pitfall. To overcome this, we designe...

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Detalles Bibliográficos
Autores principales: Mehmetoglu-Gurbuz, Tugba, Yeh, Rose, Garg, Himanshu, Joshi, Anjali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847599/
https://www.ncbi.nlm.nih.gov/pubmed/33516234
http://dx.doi.org/10.1186/s12985-021-01501-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847599/
https://www.ncbi.nlm.nih.gov/pubmed/33516234
http://dx.doi.org/10.1186/s12985-021-01501-7

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