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Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

BACKGROUND: Pain is a highly prevalent symptom experienced by patients across numerous rare musculoskeletal conditions. Much remains unknown regarding the central, neurobiological processes associated with clinical pain in musculoskeletal disease states. Fibrodysplasia ossificans progressiva (FOP) i...

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Autores principales: Peng, Ke, Karunakaran, Keerthana Deepti, Labadie, Robert, Veliu, Miranda, Cheung, Chandler, Lee, Arielle, Yu, Paul B., Upadhyay, Jaymin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847608/
https://www.ncbi.nlm.nih.gov/pubmed/33516233
http://dx.doi.org/10.1186/s13023-021-01709-4
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author Peng, Ke
Karunakaran, Keerthana Deepti
Labadie, Robert
Veliu, Miranda
Cheung, Chandler
Lee, Arielle
Yu, Paul B.
Upadhyay, Jaymin
author_facet Peng, Ke
Karunakaran, Keerthana Deepti
Labadie, Robert
Veliu, Miranda
Cheung, Chandler
Lee, Arielle
Yu, Paul B.
Upadhyay, Jaymin
author_sort Peng, Ke
collection PubMed
description BACKGROUND: Pain is a highly prevalent symptom experienced by patients across numerous rare musculoskeletal conditions. Much remains unknown regarding the central, neurobiological processes associated with clinical pain in musculoskeletal disease states. Fibrodysplasia ossificans progressiva (FOP) is an inherited condition characterized by substantial physical disability and pain. FOP arises from mutations of the bone morphogenetic protein (BMP) receptor Activin A receptor type 1 (ACVR1) causing patients to undergo painful flare-ups as well as heterotopic ossification (HO) of skeletal muscles, tendons, ligaments, and fascia. To date, the neurobiological processes that underlie pain in FOP have rarely been investigated. We examined pain and central pain mechanism in FOP as a model primary musculoskeletal condition. Central nervous system (CNS) functional properties were investigated in FOP patients (N = 17) stratified into low (0–3; 0–10 Scale) and high (≥ 4) pain cohorts using functional near-infrared spectroscopy (fNIRS). Associations among clinical pain, mental health, and physical health were also quantified using responses derived from a battery of clinical questionnaires. RESULTS: Resting-state fNIRS revealed suppressed power of hemodynamic activity within the slow-5 frequency sub-band (0.01–0.027 Hz) in the prefrontal cortex in high pain FOP patients, where reduced power of slow-5, prefrontal cortex oscillations exhibited robust negative correlations with pain levels. Higher clinical pain intensities were also associated with higher magnitudes of depressive symptoms. CONCLUSIONS: Our findings not only demonstrate a robust coupling among prefrontal cortex functionality and clinical pain in FOP but lays the groundwork for utilizing fNIRS to objectively monitor and central pain mechanisms in FOP and other musculoskeletal disorders.
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spelling pubmed-78476082021-02-01 Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva Peng, Ke Karunakaran, Keerthana Deepti Labadie, Robert Veliu, Miranda Cheung, Chandler Lee, Arielle Yu, Paul B. Upadhyay, Jaymin Orphanet J Rare Dis Research BACKGROUND: Pain is a highly prevalent symptom experienced by patients across numerous rare musculoskeletal conditions. Much remains unknown regarding the central, neurobiological processes associated with clinical pain in musculoskeletal disease states. Fibrodysplasia ossificans progressiva (FOP) is an inherited condition characterized by substantial physical disability and pain. FOP arises from mutations of the bone morphogenetic protein (BMP) receptor Activin A receptor type 1 (ACVR1) causing patients to undergo painful flare-ups as well as heterotopic ossification (HO) of skeletal muscles, tendons, ligaments, and fascia. To date, the neurobiological processes that underlie pain in FOP have rarely been investigated. We examined pain and central pain mechanism in FOP as a model primary musculoskeletal condition. Central nervous system (CNS) functional properties were investigated in FOP patients (N = 17) stratified into low (0–3; 0–10 Scale) and high (≥ 4) pain cohorts using functional near-infrared spectroscopy (fNIRS). Associations among clinical pain, mental health, and physical health were also quantified using responses derived from a battery of clinical questionnaires. RESULTS: Resting-state fNIRS revealed suppressed power of hemodynamic activity within the slow-5 frequency sub-band (0.01–0.027 Hz) in the prefrontal cortex in high pain FOP patients, where reduced power of slow-5, prefrontal cortex oscillations exhibited robust negative correlations with pain levels. Higher clinical pain intensities were also associated with higher magnitudes of depressive symptoms. CONCLUSIONS: Our findings not only demonstrate a robust coupling among prefrontal cortex functionality and clinical pain in FOP but lays the groundwork for utilizing fNIRS to objectively monitor and central pain mechanisms in FOP and other musculoskeletal disorders. BioMed Central 2021-01-30 /pmc/articles/PMC7847608/ /pubmed/33516233 http://dx.doi.org/10.1186/s13023-021-01709-4 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Peng, Ke
Karunakaran, Keerthana Deepti
Labadie, Robert
Veliu, Miranda
Cheung, Chandler
Lee, Arielle
Yu, Paul B.
Upadhyay, Jaymin
Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva
title Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva
title_full Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva
title_fullStr Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva
title_full_unstemmed Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva
title_short Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva
title_sort suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847608/
https://www.ncbi.nlm.nih.gov/pubmed/33516233
http://dx.doi.org/10.1186/s13023-021-01709-4
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