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Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases
The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases, are ubiquitously expressed in various cell types. Numerous studies have suggested that SFKs are related to signal transduction in major cardiac physiological and pathological processes, it is the activity o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847615/ https://www.ncbi.nlm.nih.gov/pubmed/33526983 http://dx.doi.org/10.7150/ijms.49241 |
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author | Zhai, Yuhong Yang, Jun Zhang, Jing Yang, Jian Li, Qi Zheng, Tao |
author_facet | Zhai, Yuhong Yang, Jun Zhang, Jing Yang, Jian Li, Qi Zheng, Tao |
author_sort | Zhai, Yuhong |
collection | PubMed |
description | The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases, are ubiquitously expressed in various cell types. Numerous studies have suggested that SFKs are related to signal transduction in major cardiac physiological and pathological processes, it is the activity of SFKs that is connected with the maintenance of cardiovascular homeostasis. Upon stimulation of various injury factors or stress, the phosphorylation state of SFKs is changed, which has been found to modulate different cardiac pathological conditions, such as hypertension, coronary heart disease, ischemic heart disease, myocardial ischemia-reperfusion injury, arrhythmia and cardiomyopathy via regulating cell growth, differentiation, movement and function, electrophysiologic signals. This review summarizes the basic information about SFKs, updates its role in the different processes underlying the development of multiple cardiovascular diseases (CVDs), and highlights their potential role as disease biomarkers and therapeutic targets, which would help understand the pathophysiology of CVDs and promote the further potential clinical adhibition. |
format | Online Article Text |
id | pubmed-7847615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-78476152021-01-31 Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases Zhai, Yuhong Yang, Jun Zhang, Jing Yang, Jian Li, Qi Zheng, Tao Int J Med Sci Review The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases, are ubiquitously expressed in various cell types. Numerous studies have suggested that SFKs are related to signal transduction in major cardiac physiological and pathological processes, it is the activity of SFKs that is connected with the maintenance of cardiovascular homeostasis. Upon stimulation of various injury factors or stress, the phosphorylation state of SFKs is changed, which has been found to modulate different cardiac pathological conditions, such as hypertension, coronary heart disease, ischemic heart disease, myocardial ischemia-reperfusion injury, arrhythmia and cardiomyopathy via regulating cell growth, differentiation, movement and function, electrophysiologic signals. This review summarizes the basic information about SFKs, updates its role in the different processes underlying the development of multiple cardiovascular diseases (CVDs), and highlights their potential role as disease biomarkers and therapeutic targets, which would help understand the pathophysiology of CVDs and promote the further potential clinical adhibition. Ivyspring International Publisher 2021-01-14 /pmc/articles/PMC7847615/ /pubmed/33526983 http://dx.doi.org/10.7150/ijms.49241 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Zhai, Yuhong Yang, Jun Zhang, Jing Yang, Jian Li, Qi Zheng, Tao Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases |
title | Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases |
title_full | Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases |
title_fullStr | Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases |
title_full_unstemmed | Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases |
title_short | Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases |
title_sort | src-family protein tyrosine kinases: a promising target for treating cardiovascular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847615/ https://www.ncbi.nlm.nih.gov/pubmed/33526983 http://dx.doi.org/10.7150/ijms.49241 |
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