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Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19

Objective: This study aimed to identify the predictive value of simple markers in routine blood and coagulation tests for the severity of coronavirus disease 2019 (COVID-19). Methods: A total of 311 consecutive COVID-19 patients, including 281 patients with mild/moderate COVID-19 and 30 patients wit...

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Autores principales: Ding, Rongrong, Yang, Zongguo, Huang, Dan, Wang, Yanbing, Li, Xiufen, Zhou, Xinlan, Yan, Li, Lu, Wei, Zhang, Zhanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847620/
https://www.ncbi.nlm.nih.gov/pubmed/33526982
http://dx.doi.org/10.7150/ijms.47494
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author Ding, Rongrong
Yang, Zongguo
Huang, Dan
Wang, Yanbing
Li, Xiufen
Zhou, Xinlan
Yan, Li
Lu, Wei
Zhang, Zhanqing
author_facet Ding, Rongrong
Yang, Zongguo
Huang, Dan
Wang, Yanbing
Li, Xiufen
Zhou, Xinlan
Yan, Li
Lu, Wei
Zhang, Zhanqing
author_sort Ding, Rongrong
collection PubMed
description Objective: This study aimed to identify the predictive value of simple markers in routine blood and coagulation tests for the severity of coronavirus disease 2019 (COVID-19). Methods: A total of 311 consecutive COVID-19 patients, including 281 patients with mild/moderate COVID-19 and 30 patients with severe/life-threatening COVID-19, were retrospectively enrolled. Logistic modeling and ROC curve analyses were used to assess the indexes for identifying disease severity. Results: Lymphocyte and eosinophil counts of COVID-19 patients in the severe/life-threatening group were significantly lower than those of patients in the mild/moderate group (P < 0.001). Coagulation parameters, high-sensitivity C-reactive protein (hsCRP) levels and procalcitonin levels were higher in the severe/life-threatening group compared with the mild/moderate group (all P < 0.05). Univariate and multivariate logistic models revealed that hsCRP and fibrinogen degradation products (FDPs) were predictors of severe COVID-19 (OR = 1.072, P = 0.036; and OR = 1.831, P = 0.036, respectively). The AUROCs of hsCRP and FDP for predicting severe/life-threatening COVID-19 were 0.850 and 0.766, respectively. The optimal cutoffs of hsCRP and FDP for the severe/life-threatening type of COVID-19 were 22.41 mg/L and 0.95 µg/ml, respectively. Conclusion: Serum CRP and FDP levels are positively related to the severity of COVID-19. This finding indicates that CRP and FDP levels may potentially be used as early predictors for severe illness and help physicians triage numerous patients in a short time.
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spelling pubmed-78476202021-01-31 Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19 Ding, Rongrong Yang, Zongguo Huang, Dan Wang, Yanbing Li, Xiufen Zhou, Xinlan Yan, Li Lu, Wei Zhang, Zhanqing Int J Med Sci Research Paper Objective: This study aimed to identify the predictive value of simple markers in routine blood and coagulation tests for the severity of coronavirus disease 2019 (COVID-19). Methods: A total of 311 consecutive COVID-19 patients, including 281 patients with mild/moderate COVID-19 and 30 patients with severe/life-threatening COVID-19, were retrospectively enrolled. Logistic modeling and ROC curve analyses were used to assess the indexes for identifying disease severity. Results: Lymphocyte and eosinophil counts of COVID-19 patients in the severe/life-threatening group were significantly lower than those of patients in the mild/moderate group (P < 0.001). Coagulation parameters, high-sensitivity C-reactive protein (hsCRP) levels and procalcitonin levels were higher in the severe/life-threatening group compared with the mild/moderate group (all P < 0.05). Univariate and multivariate logistic models revealed that hsCRP and fibrinogen degradation products (FDPs) were predictors of severe COVID-19 (OR = 1.072, P = 0.036; and OR = 1.831, P = 0.036, respectively). The AUROCs of hsCRP and FDP for predicting severe/life-threatening COVID-19 were 0.850 and 0.766, respectively. The optimal cutoffs of hsCRP and FDP for the severe/life-threatening type of COVID-19 were 22.41 mg/L and 0.95 µg/ml, respectively. Conclusion: Serum CRP and FDP levels are positively related to the severity of COVID-19. This finding indicates that CRP and FDP levels may potentially be used as early predictors for severe illness and help physicians triage numerous patients in a short time. Ivyspring International Publisher 2021-01-14 /pmc/articles/PMC7847620/ /pubmed/33526982 http://dx.doi.org/10.7150/ijms.47494 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Ding, Rongrong
Yang, Zongguo
Huang, Dan
Wang, Yanbing
Li, Xiufen
Zhou, Xinlan
Yan, Li
Lu, Wei
Zhang, Zhanqing
Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
title Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
title_full Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
title_fullStr Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
title_full_unstemmed Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
title_short Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19
title_sort identification of parameters in routine blood and coagulation tests related to the severity of covid-19
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847620/
https://www.ncbi.nlm.nih.gov/pubmed/33526982
http://dx.doi.org/10.7150/ijms.47494
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